International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …
therapeutics and various drugs in development. Their diversity of structure and function …
Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response
The role of serotonin in depression and antidepressant treatment remains unresolved
despite decades of research. In this paper, we make three major claims. First, serotonin …
despite decades of research. In this paper, we make three major claims. First, serotonin …
Pharmacological treatment of anxiety disorders: the role of the HPA axis
GE Tafet, CB Nemeroff - Frontiers in psychiatry, 2020 - frontiersin.org
Stress in general, and early life stress in particular, has been associated with the
development of anxiety and mood disorders. The molecular, biological and psychological …
development of anxiety and mood disorders. The molecular, biological and psychological …
The implication of 5-HT receptor family members in aggression, depression and suicide: similarity and difference
NK Popova, AS Tsybko, VS Naumenko - International journal of molecular …, 2022 - mdpi.com
Being different multifactorial forms of psychopathology, aggression, depression and suicidal
behavior, which is considered to be violent aggression directed against the self, have …
behavior, which is considered to be violent aggression directed against the self, have …
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors
The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in
major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in …
major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in …
The role of the serotonin receptor subtypes 5-HT1A and 5-HT7 and its interaction in emotional learning and memory
O Stiedl, E Pappa, Å Konradsson-Geuken… - Frontiers in …, 2015 - frontiersin.org
Serotonin [5-hydroxytryptamine (5-HT)] is a multifunctional neurotransmitter innervating
cortical and limbic areas involved in cognition and emotional regulation. Dysregulation of …
cortical and limbic areas involved in cognition and emotional regulation. Dysregulation of …
Synaptic remodeling depends on signaling between serotonin receptors and the extracellular matrix
Rewiring of synaptic circuitry pertinent to memory formation has been associated with
morphological changes in dendritic spines and with extracellular matrix (ECM) remodeling …
morphological changes in dendritic spines and with extracellular matrix (ECM) remodeling …
Understanding the role of GPCR heteroreceptor complexes in modulating the brain networks in health and disease
DO Borroto-Escuela, J Carlsson… - Frontiers in cellular …, 2017 - frontiersin.org
The introduction of allosteric receptor–receptor interactions in G protein-coupled receptor
(GPCR) heteroreceptor complexes of the central nervous system (CNS) gave a new …
(GPCR) heteroreceptor complexes of the central nervous system (CNS) gave a new …
Multiple roles of serotonin in pain control mechanisms—implications of 5-HT7 and other 5-HT receptor types
F Viguier, B Michot, M Hamon, S Bourgoin - European journal of …, 2013 - Elsevier
Abstract Among monoamine neurotransmitters, serotonin (5-HT) is known to play complex
modulatory roles in pain signaling mechanisms since the first reports, about forty years ago …
modulatory roles in pain signaling mechanisms since the first reports, about forty years ago …