Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …

Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …

The intestine is a complex organ that promotes digestion, extracts nutrients, participates in
immune surveillance, maintains critical symbiotic relationships with microbiota and affects …

Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …

Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids.
However, it has a limited ability to expand by recruiting and/or differentiating available …

Adipogenesis is the process by which precursor stem cells differentiate into lipid laden
adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene …

Obesity originates from an imbalance between caloric intake and energy expenditure that
promotes adipose tissue expansion, which is necessary to buffer nutrient excess. Patients …

Fibrosis disrupts adipose tissue (AT) homeostasis and exacerbates metabolic dysfunction
upon chronic caloric excess. The molecular mechanisms linking adipocyte plasticity to AT …

Insulin resistance is a multi-faceted disruption of the communication between insulin and the
interior of a target cell. The underlying cause of insulin resistance appears to be …