Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations

J Phua, L Weng, L Ling, M Egi, CM Lim… - The lancet respiratory …, 2020 - thelancet.com
Summary As coronavirus disease 2019 (COVID-19) spreads across the world, the intensive
care unit (ICU) community must prepare for the challenges associated with this pandemic …

[HTML][HTML] SARS-CoV-2 vaccines: status report

F Amanat, F Krammer - Immunity, 2020 - cell.com
SARS-CoV-2, the causal agent of COVID-19, first emerged in late 2019 in China. It has since
infected more than 870,000 individuals and caused more than 43,000 deaths globally. Here …

[HTML][HTML] Immunogenicity of a DNA vaccine candidate for COVID-19

TRF Smith, A Patel, S Ramos, D Elwood, X Zhu… - Nature …, 2020 - nature.com
The coronavirus family member, SARS-CoV-2 has been identified as the causal agent for
the pandemic viral pneumonia disease, COVID-19. At this time, no vaccine is available to …

Current status of potential therapeutic candidates for the COVID-19 crisis

J Zhang, B Xie, K Hashimoto - Brain, behavior, and immunity, 2020 - Elsevier
Abstract As of April 15, 2020, the ongoing coronavirus disease 2019 (COVID-2019)
pandemic has swept through 213 countries and infected more than 1,870,000 individuals …

Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial

K Modjarrad, CC Roberts, KT Mills… - The Lancet Infectious …, 2019 - thelancet.com
Summary Background Middle East respiratory syndrome (MERS) coronavirus causes a
highly fatal lower-respiratory tract infection. There are as yet no licensed MERS vaccines or …

[HTML][HTML] SARS and MERS: recent insights into emerging coronaviruses

E De Wit, N Van Doremalen, D Falzarano… - Nature reviews …, 2016 - nature.com
Abstract The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in
2012 marked the second introduction of a highly pathogenic coronavirus into the human …

[HTML][HTML] MERS-CoV: understanding the latest human coronavirus threat

A Chafekar, BC Fielding - Viruses, 2018 - mdpi.com
Human coronaviruses cause both upper and lower respiratory tract infections in humans. In
2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe …

[HTML][HTML] Cellular and molecular pathways of COVID-19 and potential points of therapeutic intervention

JP Hussman - Frontiers in pharmacology, 2020 - frontiersin.org
With the objective of linking early findings relating to the novel SARS-CoV-2 coronavirus
with potentially informative findings from prior research literature and to promote …

[HTML][HTML] Passive immunotherapy of viral infections:'super-antibodies' enter the fray

LM Walker, DR Burton - Nature Reviews Immunology, 2018 - nature.com
Antibodies have been used for more than 100 years in the therapy of infectious diseases,
but a new generation of highly potent and/or broadly cross-reactive human monoclonal …

Current progress in innovative engineered antibodies

WR Strohl - Protein & cell, 2018 - academic.oup.com
Abstract As of May 1, 2017, 74 antibody-based molecules have been approved by a
regulatory authority in a major market. Additionally, there are 70 and 575 antibody-based …