Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Alzheimer's disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ)
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …

Although dormancy is thought to play a key role in the metastasis of breast tumor cells to the
brain, our knowledge of the molecular mechanisms regulating disseminated tumor cell …

Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

Neural signalling within the central nervous system (CNS) requires a highly controlled
microenvironment. Cells at three key interfaces form barriers between the blood and the …

The blood–brain barrier, which is formed by the endothelial cells that line cerebral
microvessels, has an important role in maintaining a precisely regulated microenvironment …

As the primary protective barrier for neurons in the brain, the blood–brain barrier (BBB)
exists between the blood microcirculation system and the brain parenchyma. The normal …

Vascular dysfunction has a critical role in Alzheimer's disease (AD). Recent data from brain
imaging studies in humans and animal models suggest that cerebrovascular dysfunction …

Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

1. The blood–brain barrier is essential for the maintenance and regulation of the neural
microenvironment. The main characteristic features of blood–brain barrier endothelial cells …