The endocytosis mechanism is a complicated system that is essential for cell signaling and
survival. Megalin, a membrane-associated endocytic receptor, and its related proteins such …

The architectural design of our kidneys is amazingly complex, and culminates in the 3D
structure of the glomerular filter. During filtration, plasma passes through a sieve consisting …

During development, animals generate distinct cell populations with specific identities,
functions, and morphologies. We mapped transcriptionally distinct populations across …

Identification of single-gene causes of steroid-resistant nephrotic syndrome (SRNS) has
furthered the understanding of the pathogenesis of this disease. Here, using a combination …

At least 10% of adults and nearly all children who receive renal-replacement therapy have
an inherited kidney disease. These patients rarely die when their disease progresses and …

Abstract FlyAtlas 2 (flyatlas2. org) is a database and web application for studying the
expression of the genes of Drosophila melanogaster in different tissues of adults and larvae …

Steroid-resistant nephrotic syndrome (SRNS) is a frequent cause of progressive renal
function decline and affects millions of people. In a recent study, 30% of SRNS cases …

Although the genetic basis of many kidney diseases is being rapidly elucidated, their
experimental study remains problematic owing to the lack of suitable models. The fruitfly …

Recent advances in single-cell sequencing provide a unique opportunity to gain novel
insights into the diversity, lineage, and functions of cell types constituting a tissue/organ …

Receptor-mediated endocytosis in renal proximal tubule epithelial cells (PTECs) is important
for the reabsorption and metabolization of proteins and other substances, including carrier …