[HTML][HTML] Autophagy in sarcopenia: Possible mechanisms and novel therapies

G Xie, H Jin, H Mikhail, V Pavel, G Yang, B Ji… - Biomedicine & …, 2023 - Elsevier
With global population aging, age-related diseases, especially sarcopenia, have attracted
much attention in recent years. Characterized by low muscle strength, low muscle quantity or …

Intracellular to interorgan mitochondrial communication in striated muscle in health and disease

NT Boardman, G Trani, M Scalabrin… - Endocrine …, 2023 - academic.oup.com
Mitochondria sense both biochemical and energetic input in addition to communicating
signals regarding the energetic state of the cell. Increasingly, these signaling organelles are …

Sepsis-associated muscle wasting: a comprehensive review from bench to bedside

I Yoshihara, Y Kondo, K Okamoto… - International Journal of …, 2023 - mdpi.com
Sepsis-associated muscle wasting (SAMW) is characterized by decreased muscle mass,
reduced muscle fiber size, and decreased muscle strength, resulting in persistent physical …

METTL3 regulates osteoclast biological behaviors via iNOS/NO-mediated mitochondrial dysfunction in inflammatory conditions

D Li, J He, C Fang, Y Zhang, M He, Z Zhang… - International journal of …, 2023 - mdpi.com
Excessive differentiation of osteoclasts contributes to the disruption of bone homeostasis in
inflammatory bone diseases. Methyltransferase-like 3 (METTL3), the core methyltransferase …

[HTML][HTML] Exercise, mitochondrial dysfunction and inflammasomes in skeletal muscle

MB Slavin, P Khemraj, DA Hood - Biomedical Journal, 2024 - Elsevier
In the broad field of inflammation, skeletal muscle is a tissue that is understudied. Yet it
represents about 40% of body mass in non-obese individuals and is therefore of …

Targeting NAT10 protects against sepsis-induced skeletal muscle atrophy by inhibiting ROS/NLRP3

C Wang, Y Liu, Y Zhang, D Wang, L Xu, Z Li, X Bai… - Life Sciences, 2023 - Elsevier
Aims To identify N-acetyltransferase 10 (NAT10) and its downstream signaling pathways in
myocytes and skeletal muscle, and to investigate its role in inflammation-induced muscle …

Faecal microbiota transplantation from young rats attenuates age‐related sarcopenia revealed by multiomics analysis

X Mo, L Shen, R Cheng, P Wang, L Wen… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Gut microbiota plays a key role in the development of sarcopenia via the 'gut‐
muscle'axis, and probiotics‐based therapy might be a strategy for sarcopenia. Fecal …

MiR-495–3p attenuates cell pyroptosis and endometritis through inhibiting the activation of NLRP3 inflammasome in bovine

Z Wu, G Deng, X Ma, T Zhang, S Guo, Q Zhou… - Molecular …, 2023 - Elsevier
Abstract miR-495 is aberrantly expressed and affects the progression of inflammation in
various diseases. However, the mechanisms of miR-495 in bovine endometritis remain …

The NLRP3 inflammasome: A vital player in inflammation and mediating the anti-inflammatory effect of CBD

F Chu, X Wang, B Li, L Xu, B Di - Inflammation Research, 2024 - Springer
Background The NLRP3 inflammasome is a vital player in the emergence of inflammation.
The priming and activation of the NLRP3 inflammasome is a major trigger for inflammation …

Smoking cessation only partially reverses cardiac metabolic and structural remodeling in mice

J Aid, AT Tanjeko, J Serré, M Eggelbusch… - Acta …, 2024 - Wiley Online Library
Aims Active cigarette smoking is a major risk factor for chronic obstructive pulmonary
disease that remains elevated after cessation. Skeletal muscle dysfunction has been well …