Current understanding of the molecular and cellular pathology of diabetic retinopathy

DA Antonetti, PS Silva, AW Stitt - Nature Reviews Endocrinology, 2021 - nature.com
Diabetes mellitus has profound effects on multiple organ systems; however, the loss of
vision caused by diabetic retinopathy might be one of the most impactful in a patient's life …

Diabetes mellitus: an overview of the types, symptoms, complications and management.

L Cloete - Nursing Standard (Royal College of Nursing (Great …, 2021 - europepmc.org
The incidence of diabetes mellitus is rapidly increasing, and this condition often results in
significant metabolic disease and severe complications. Nurses have a crucial role in …

Diabetic macular edema: current understanding, molecular mechanisms and therapeutic implications

J Zhang, J Zhang, C Zhang, J Zhang, L Gu, D Luo… - Cells, 2022 - mdpi.com
Diabetic retinopathy (DR), with increasing incidence, is the major cause of vision loss and
blindness worldwide in working-age adults. Diabetic macular edema (DME) remains the …

Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications, and other age-related diseases

CG Schalkwijk, CDA Stehouwer - Physiological reviews, 2020 - journals.physiology.org
The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Early detection of diabetic retinopathy using PCA-firefly based deep learning model

TR Gadekallu, N Khare, S Bhattacharya, S Singh… - Electronics, 2020 - mdpi.com
Diabetic Retinopathy is a major cause of vision loss and blindness affecting millions of
people across the globe. Although there are established screening methods-fluorescein …

Mechanistic pathogenesis of endothelial dysfunction in diabetic nephropathy and retinopathy

J Yang, Z Liu - Frontiers in endocrinology, 2022 - frontiersin.org
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of
diabetes. Microvascular endothelial cells are thought to be the major targets of …

Role of inflammation in diabetic retinopathy

A Rübsam, S Parikh, PE Fort - International journal of molecular sciences, 2018 - mdpi.com
Diabetic retinopathy is a common complication of diabetes and remains the leading cause of
blindness among the working-age population. For decades, diabetic retinopathy was …

[HTML][HTML] Diabetic retinopathy: current understanding, mechanisms, and treatment strategies

EJ Duh, JK Sun, AW Stitt - JCI insight, 2017 - ncbi.nlm.nih.gov
Diabetic retinopathy (DR) causes significant visual loss on a global scale. Treatments for the
vision-threatening complications of diabetic macular edema (DME) and proliferative diabetic …

Neurodegeneration in diabetic retinopathy: does it really matter?

R Simó, AW Stitt, TW Gardner - Diabetologia, 2018 - Springer
The concept of diabetic retinopathy as a microvascular disease has evolved, in that it is now
considered a more complex diabetic complication in which neurodegeneration plays a …

Optical coherence tomography angiography: a comprehensive review of current methods and clinical applications

AH Kashani, CL Chen, JK Gahm, F Zheng… - Progress in retinal and …, 2017 - Elsevier
OCT has revolutionized the practice of ophthalmology over the past 10–20 years. Advances
in OCT technology have allowed for the creation of novel OCT-based methods. OCT …