CD8 T cells respond to viral infections but also participate in defense against bacterial and
protozoal infections. In the last few years, as new methods to accurately quantify and …

Trypanotolerance is the capacity of certain West-African, taurine breeds of cattle to remain
productive and gain weight after trypanosome infection. Laboratory studies, comparing …

Gamma interferon (IFN-gamma) plays an important role in experimental Trypanosoma cruzi
infections, presumably by controlling the early replication of parasites in host macrophages …

The life cycle of the protozoan parasite Trypanosoma cruzi in mammalian hosts includes
both non‐dividing trypomastigote forms which circulate in the blood and replicating …

CD8+ T cells are crucial to the control of Trypanosoma cruzi infection and probably act via
multiple mechanisms, the most important being the production of interferon‐γ (IFN‐γ). In the …

Adaptive immunity controls Trypanosoma cruzi infection, but the protozoan parasite persists
and causes Chagas disease. T cells undergo apoptosis, and the efferocytosis of apoptotic …

Background Reactivation of chronic Chagas disease, which occurs in approximately 20% of
patients coinfected with HIV/Trypanosoma cruzi (T. cruzi), is commonly characterized by …

Chagas' disease is a zoonosis prevalent in Latin America that is caused by the protozoan
Trypanosoma cruzi. The immunopathogenesis of cardiomyopathy, the main clinical problem …

Previously we found that the frequency of IFN-γ-producing CD8+ T cells specific for
Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas …

In mammals, chronic diseases resulting from infectious agents have been associated with
functional T cell response deficiency, a high frequency of terminally differentiated T cells, the …