[PDF][PDF] The immunology of sepsis

T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021 - cell.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

The Japanese clinical practice guidelines for management of sepsis and septic shock 2020 (J-SSCG 2020)

M Egi, H Ogura, T Yatabe, K Atagi, S Inoue, T Iba… - Journal of intensive …, 2021 - Springer
Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Neutrophil Extracellular Traps (NETs) and Covid-19: A new frontiers for therapeutic modality

HM Al-Kuraishy, AI Al-Gareeb, HA Al-Hussaniy… - International …, 2022 - Elsevier
Abstract Coronavirus disease 2019 (Covid-19) is a worldwide infectious disease caused by
severe acute respiratory coronavirus 2 (SARS-CoV-2). In severe SARS-CoV-2 infection …

Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Pharmacological agents targeting thromboinflammation in COVID-19: review and implications for future research

B Bikdeli, MV Madhavan, A Gupta… - Thrombosis and …, 2020 - thieme-connect.com
Coronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is a viral illness
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The …

Endothelial responses in sepsis

J Joffre, J Hellman, C Ince… - American journal of …, 2020 - atsjournals.org
Endothelial cells (ECs) are vascular, nonconventional immune cells that play a major role in
the systemic response after bacterial infection to limit its dissemination. Triggered by …

Heparin as a therapy for COVID-19: current evidence and future possibilities

JA Hippensteel, WB LaRiviere… - … of Physiology-Lung …, 2020 - journals.physiology.org
Coronavirus disease 2019 (COVID-19), the clinical syndrome associated with infection by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted nearly every …

Diagnosis and management of sepsis‐induced coagulopathy and disseminated intravascular coagulation

T Iba, JH Levy, TE Warkentin, J Thachil… - … of Thrombosis and …, 2019 - Wiley Online Library
The International Society of Thrombosis and Haemostasis (ISTH) in 2001 defined
disseminated intravascular congestion (DIC) as “an ac‐quired syndrome characterized by …

Sepsis-induced coagulopathy and disseminated intravascular coagulation

T Iba, M Levi, JH Levy - Seminars in thrombosis and …, 2020 - thieme-connect.com
Disseminated intravascular coagulation (DIC) has been recognized as a deadly
complication in sepsis, and its early recognition followed by appropriate management of the …

Prognostic and predictive enrichment in sepsis

NL Stanski, HR Wong - Nature Reviews Nephrology, 2020 - nature.com
Sepsis is a heterogeneous disease state that is both common and consequential in critically
ill patients. Unfortunately, the heterogeneity of sepsis at the individual patient level has …