[HTML][HTML] Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype
R Kumari, P Jat - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …
Inflammation, Aging, and Cardiovascular Disease: JACC Review Topic of the Week
L Liberale, L Badimon, F Montecucco… - Journal of the American …, 2022 - jacc.org
Aging and inflammation both contribute pivotally to cardiovascular (CV) and cerebrovascular
disease, the leading causes of death and disability worldwide. The concept of inflamm-aging …
disease, the leading causes of death and disability worldwide. The concept of inflamm-aging …
Restoring metabolism of myeloid cells reverses cognitive decline in ageing
Ageing is characterized by the development of persistent pro-inflammatory responses that
contribute to atherosclerosis, metabolic syndrome, cancer and frailty,–. The ageing brain is …
contribute to atherosclerosis, metabolic syndrome, cancer and frailty,–. The ageing brain is …
Immunology of aging: the birth of inflammaging
The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an
evolutionary or rather a revolutionary conceptualization of the immune changes in response …
evolutionary or rather a revolutionary conceptualization of the immune changes in response …
[HTML][HTML] The gut microbiome, aging, and longevity: a systematic review
Aging is determined by complex interactions among genetic and environmental factors.
Increasing evidence suggests that the gut microbiome lies at the core of many age …
Increasing evidence suggests that the gut microbiome lies at the core of many age …
[HTML][HTML] The interplay between the gut microbiome and the immune system in the context of infectious diseases throughout life and the role of nutrition in optimizing …
SP Wiertsema, J van Bergenhenegouwen, J Garssen… - Nutrients, 2021 - mdpi.com
Infectious diseases and infections remain a leading cause of death in low-income countries
and a major risk to vulnerable groups, such as infants and the elderly. The immune system …
and a major risk to vulnerable groups, such as infants and the elderly. The immune system …
From discoveries in ageing research to therapeutics for healthy ageing
For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
The role of nutrition in inflammaging
P Di Giosia, CA Stamerra, P Giorgini… - Ageing research …, 2022 - Elsevier
Background Old age is characterized by a peculiar low-grade, chronic, and “sterile”
inflammatory state, which has been termed “inflammaging.” This is believed to substantially …
inflammatory state, which has been termed “inflammaging.” This is believed to substantially …
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …