Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits

KJ Ressler, S Berretta, VY Bolshakov… - Nature Reviews …, 2022 - nature.com
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …

The role of the salience network in cognitive and affective deficits

J Schimmelpfennig, J Topczewski… - Frontiers in human …, 2023 - frontiersin.org
Analysis and interpretation of studies on cognitive and affective dysregulation often draw
upon the network paradigm, especially the Triple Network Model, which consists of the …

Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain

MN Tran, KR Maynard, A Spangler, LA Huuki… - Neuron, 2021 - cell.com
Single-cell gene expression technologies are powerful tools to study cell types in the human
brain, but efforts have largely focused on cortical brain regions. We therefore created a …

Neurocognitive effects of stress: a metaparadigm perspective

EJ Kim, JJ Kim - Molecular Psychiatry, 2023 - nature.com
Stressful experiences, both physical and psychological, that are overwhelming (ie,
inescapable and unpredictable), can measurably affect subsequent neuronal properties and …

[HTML][HTML] Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders

SB Sartori, N Singewald - Pharmacology & therapeutics, 2019 - Elsevier
Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

Psychological processes mediating the association between developmental trauma and specific psychotic symptoms in adults: A systematic review and meta‐analysis

MAP Bloomfield, T Chang, MJ Woodl… - World …, 2021 - Wiley Online Library
Experiencing psychological trauma during childhood and/or adolescence is associated with
an increased risk of psychosis in adulthood. However, we lack a clear knowledge of how …

Resilience after trauma: The role of memory suppression

A Mary, J Dayan, G Leone, C Postel, F Fraisse, C Malle… - Science, 2020 - science.org
INTRODUCTION One of the fundamental questions in clinical neuroscience is why some
individuals can cope with traumatic events, while others remain traumatized by a haunting …

Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior

GW Zhang, L Shen, C Tao, AH Jung, B Peng, Z Li… - Nature …, 2021 - nature.com
Anxiety is a negative emotional state that is overly displayed in anxiety disorders and
depression. Although anxiety is known to be controlled by distributed brain networks, key …

Large-scale functional brain network architecture changes associated with trauma-related dissociation

LAM Lebois, M Li, JT Baker, JD Wolff… - American Journal of …, 2021 - Am Psychiatric Assoc
Objective: Dissociative experiences commonly occur in response to trauma, and while their
presence strongly affects treatment approaches in posttraumatic spectrum disorders, their …

Neural contributors to trauma resilience: a review of longitudinal neuroimaging studies

AR Roeckner, KI Oliver, LAM Lebois… - Translational …, 2021 - nature.com
Resilience in the face of major life stressors is changeable over time and with experience.
Accordingly, differing sets of neurobiological factors may contribute to an adaptive stress …