Recent advances in vitamin D research indicate that this vitamin, a secosteroid hormone,
has beneficial effects on several body systems other than the musculoskeletal system. Both …

The pathophysiology of Polycystic Ovary Syndrome (PCOS) is quite complex and different
mechanisms could contribute to hyperandrogenism and anovulation, which are the main …

Sirtuins are a family of highly evolutionarily conserved nicotinamide adenine nucleotide‐
dependent histone deacetylases. Sirtuin‐3 (SIRT 3) is a member of the sirtuin family that is …

Oxidative stress and mitochondrial dysfunction contribute greatly to fluoride-induced
cognitive impairment and behavioural disorders. Honokiol, a natural biphenolic compound …

Scope Sirtuin 1/peroxisome proliferator‐activated receptor gamma co‐activator 1 alpha
(SIRT1/PGC‐1α) pathway activation is known to promote thermogenesis and mitochondrial …

Aim High dose of fluoride intake is associated with toxic effects on liver and kidney tissues.
One approach to tackle these toxicities is using natural antioxidants as supplements. This …

Melatonin is a pleiotropic hormone with several functions. It binds to specific receptors and
to a number of cytosolic proteins, activating a vast array of signalling pathways. Its potential …

More effective treatments for diabetic nephropathy remain a major unmet clinical need.
Increased oxidative stress is one of the most important pathological mechanisms that lead to …

The purpose of this review is to attempt to outline the potential role of fluoride in the
pathogenesis of brain tumours, including glioblastoma (GBM). In this paper, we show for the …

Mitochondrial reactive oxygen species (ROS) production has been implicated in the
pathogenesis of fluoride toxicity in liver. Melatonin, an indolamine synthesized in the pineal …