Objectives: The study sought to test whether high-dose statin treatment would result in
greater reductions in plaque inflammation than low-dose statins, using fluorodeoxyglucose …

Anti-inflammatory activities of statins in atherosclerosis have been well documented by both
basic research and clinical studies. Statins have been introduced in the 1980s as 3-hydroxy …

Rationale: The high morbidity/mortality of atherosclerosis is typically precipitated by plaque
rupture and consequent thrombosis. However, research on underlying mechanisms and …

Background Elevated levels of total cholesterol and low‐density lipoprotein play an
important role in the development of atheromas and, therefore, in cardiovascular diseases …

The objective of this study was to evaluate the effects of specific NF-κB inhibitor pyrrolidine
dithiocarbamate (PDTC) on inflammatory response and cardiac function in a rat model of …

Objective To examine the influence of walking at different times of day on lipids and
inflammatory markers in sedentary patients with coronary artery disease (CAD). Methods A …

Featured Application The peroxygenase activity of CYP102A1 can be used to prepare
atorvastatin drug metabolites and possibly other drugs for biotechnological applications …

Dyslipidemia due to renal insufficiency is a common complication in patients with chronic
kidney diseases (CKD), and a major risk factor for the development of cardiovascular events …

Background The objective of this nationwide retrospective cohort study was to examine the
renal outcomes of HMG‐CoA reductase inhibitor (statin) initiators. Methods The patients who …

Purpose There is an unmet need for strategies to prevent atherosclerotic cardiovascular
disease in Singapore. The main objective of this study was to investigate Singapore …