Simple Summary Cancer immunotherapy is currently focused mainly on the enhancement of
the effector function of T cells. However, dendritic cells (DCs) are needed to prime T cells …

FLT3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is
important for the normal development of stem cells and the immune system. The ligand for …

FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost
exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces …

Hematopoiesis, the process by which the hematopoietic stem cells and progenitors
differentiate into blood cells of various lineages, involves complex interactions of …

Background Recent studies have suggested that ex vivo expansion of autologous
hematopoietic cells could be a therapy of choice for the treatment of bone marrow failure …

Acute myeloid leukemia (AML) is a heterogeneous disease caused by several gene
mutations and cytogenetic abnormalities affecting differentiation and proliferation of myeloid …

Abstract Development of mammalian B-lineage cells is characterized by progression
through a series of checkpoints defined primarily by rearrangement and expression of …

Abstract Interleukin-15 (IL-15) is produced by human bone marrow (BM) stromal cells and
can induce CD34+ hematopoietic progenitor cells (HPCs) to differentiate into CD56+ CD3 …

The FLT3 receptor tyrosine kinase is highly expressed in most acute leukemias and
frequently mutated in acute myeloid leukemia (AML). The mutated form of the receptor is …

Aberrant expression of FLT3 has been found in most cases of B-lineage ALL and AML, and
subsets of T cell ALL, CML in blast crisis and CLL. In 20% of patients with AML the receptor …