Recent advances in multi-component reactions and their mechanistic insights: a triennium review

SE John, S Gulati, N Shankaraiah - Organic Chemistry Frontiers, 2021 - pubs.rsc.org
Multi-component reactions (MCRs) are considered to be an important methodological
arsenal in synthetic and medicinal chemistry. These reactions have been strategically …

Heteroatom–heteroatom bond formation in natural product biosynthesis

AJ Waldman, TL Ng, P Wang, EP Balskus - Chemical Reviews, 2017 - ACS Publications
Natural products that contain functional groups with heteroatom-heteroatom linkages (X–X,
where X= N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and …

Photocatalytic Radical Trifluoromethylation/Cyclization Cascade: Synthesis of CF3-Containing Pyrazolines and Isoxazolines

Q Wei, JR Chen, XQ Hu, XC Yang, B Lu, WJ Xiao - Organic letters, 2015 - ACS Publications
A general visible light induced photoredox-catalyzed radical trifluoromethylation/cyclization
cascade of β-aryl-β, γ-unsaturated hydrazones and oximes is described. The protocol …

[HTML][HTML] Development of Trimethoprim Drug and Innovation of Sulfazane-Trimethoprim Derivatives as Anticancer Agents

NM Aljamali, IKA Alsabri - … and Pharmacology Journal, 2020 - biomedpharmajournal.org
Cancer tumors cause not few deaths among the total deaths in the world, despite the great
progress in the treatment of cancer, so it has become necessary to understand the molecular …

2‐Isoxazolines: A synthetic and medicinal overview

G Kumar, R Shankar - ChemMedChem, 2021 - Wiley Online Library
Isoxazolines are nitrogen‐and oxygen‐containing five‐membered heterocyclic scaffolds
with extensive biological activities. This framework can be readily obtained in good to …

[PDF][PDF] SYNTHESIS OF DRUG DERIVATIVES AS INHIBITORS OF CANCEROUS CELLS.

HK Abdullabass, AM Jawad… - Biochemical & Cellular …, 2020 - researchgate.net
Cancerous tumors are among the most dangerous diseases that have spread in the current
century and their danger is increased by the lack of precise treatment that eliminates them …

Updates on hypervalent-iodine reagents: metal-free functionalisation of alkenes, alkynes and heterocycles

A Dahiya, AK Sahoo, N Chakraborty, B Das… - Organic & Biomolecular …, 2022 - pubs.rsc.org
Hypervalent iodine (HVI) chemistry is a rapidly growing subdomain of contemporary organic
chemistry because of its enormous synthetic applications. The high nucleofugality of the …

Water‐Assisted Nitrile Oxide Cycloadditions: Synthesis of Isoxazoles and Stereoselective Syntheses of Isoxazolines and 1, 2, 4‐Oxadiazoles

C Kesornpun, T Aree, C Mahidol… - Angewandte Chemie …, 2016 - Wiley Online Library
Conventional methods generate nitrile oxides from oxime halides in organic solvents under
basic conditions. However, the present work revealed that water‐assisted generation of …

Diverse applications of nitrones for the synthesis of heterocyclic compounds

LL Anderson - Asian Journal of Organic Chemistry, 2016 - Wiley Online Library
Although best known for their [3+ 2]‐dipolar cycloaddition reactivity and use in the
preparation of isoxazolines and isoxazolidines, nitrones are versatile reagents that undergo …

Electrochemical Chalcogenation of β,γ‐Unsaturated Amides and Oximes to Corresponding Oxazolines and Isoxazolines

S Mallick, M Baidya, K Mahanty, D Maiti… - Advanced Synthesis …, 2020 - Wiley Online Library
The current report represents a transition‐metal‐free synthesis of oxazoline and isoxazoline
derivatives by a tandem electro‐oxidative chalcogenation‐cyclization process. Both C− Se …