Multiscale cancer modeling

TS Deisboeck, Z Wang, P Macklin… - Annual review of …, 2011 - annualreviews.org
Simulating cancer behavior across multiple biological scales in space and time, ie,
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …

Integrative mathematical oncology

ARA Anderson, V Quaranta - Nature Reviews Cancer, 2008 - nature.com
Cancer research attracts broad resources and scientists from many disciplines, and has
produced some impressive advances in the treatment and understanding of this disease …

[图书][B] Evolutionary dynamics: exploring the equations of life

MA Nowak - 2006 - books.google.com
At a time of unprecedented expansion in the life sciences, evolution is the one theory that
transcends all of biology. Any observation of a living system must ultimately be interpreted in …

Nonlinear modelling of cancer: bridging the gap between cells and tumours

JS Lowengrub, HB Frieboes, F Jin, YL Chuang, X Li… - …, 2009 - iopscience.iop.org
Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …

Three-dimensional multispecies nonlinear tumor growth—I: model and numerical method

SM Wise, JS Lowengrub, HB Frieboes… - Journal of theoretical …, 2008 - Elsevier
This is the first paper in a two-part series in which we develop, analyze, and simulate a
diffuse interface continuum model of multispecies tumor growth and tumor-induced …

[图书][B] Multiscale modeling of cancer: an integrated experimental and mathematical modeling approach

V Cristini, J Lowengrub - 2010 - books.google.com
Mathematical modeling, analysis and simulation are set to play crucial roles in explaining
tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial …

On the foundations of cancer modelling: selected topics, speculations, and perspectives

N Bellomo, NK Li, PK Maini - Mathematical Models and Methods in …, 2008 - World Scientific
This paper presents a critical review of selected topics related to the modelling of cancer
onset, evolution and growth, with the aim of illustrating, to a wide applied mathematical …

Multiscale modelling and nonlinear simulation of vascular tumour growth

P Macklin, S McDougall, ARA Anderson… - Journal of mathematical …, 2009 - Springer
In this article, we present a new multiscale mathematical model for solid tumour growth
which couples an improved model of tumour invasion with a model of tumour-induced …

3D multi-cell simulation of tumor growth and angiogenesis

A Shirinifard, JS Gens, BL Zaitlen, NJ Popławski… - PloS one, 2009 - journals.plos.org
We present a 3D multi-cell simulation of a generic simplification of vascular tumor growth
which can be easily extended and adapted to describe more specific vascular tumor types …

Nonlinear simulations of solid tumor growth using a mixture model: invasion and branching

V Cristini, X Li, JS Lowengrub, SM Wise - Journal of mathematical biology, 2009 - Springer
We develop a thermodynamically consistent mixture model for avascular solid tumor growth
which takes into account the effects of cell-to-cell adhesion, and taxis inducing chemical and …