Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the
world. There is growing evidence that they could also be promising therapeutic targets in a …

Adenosine triphosphate (ATP) is actively released in the extracellular environment in
response to tissue damage and cellular stress. Through the activation of P2X and P2Y …

Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …

Adenosine is an autacoid that plays a critical role in regulating cardiac function, including
heart rate, contractility, and coronary flow. In this chapter, current knowledge of the functions …

This review is a historical account about purinergic signalling in the heart, for readers to see
how ideas and understanding have changed as new experimental results were published …

Despite increasing availability and more successful interventional approaches to restore
coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of …

The purine nucleoside adenosine is an important regulator within the cardiovascular system,
and throughout the body. Released in response to perturbations in energy state, among …

Adenosine, formed primarily via hydrolysis of 5′-AMP, has been historically dubbed a
“retaliatory” metabolite due to enhanced local release and beneficial actions during …

The cardioprotection afforded by ischemic preconditioning (IPC) and ischemic
postconditioning (PC) are receptor mediated. In this review, we will focus on the major …