African genetic diversity and adaptation inform a precision medicine agenda
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …
humans more than 300,000 years ago, has resulted in high genetic diversity and …
Going global by adapting local: A review of recent human adaptation
The spread of modern humans across the globe has led to genetic adaptations to diverse
local environments. Recent developments in genomic technologies, statistical analyses, and …
local environments. Recent developments in genomic technologies, statistical analyses, and …
Genome-wide polygenic score to predict chronic kidney disease across ancestries
Chronic kidney disease (CKD) is a common complex condition associated with high
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …
[HTML][HTML] The African genome variation project shapes medical genetics in Africa
Given the importance of Africa to studies of human origins and disease susceptibility,
detailed characterization of African genetic diversity is needed. The African Genome …
detailed characterization of African genetic diversity is needed. The African Genome …
Chronic kidney disease in low-and middle-income countries
JW Stanifer, A Muiru, TH Jafar… - Nephrology Dialysis …, 2016 - academic.oup.com
Most of the global burden of chronic kidney disease (CKD) is occurring in low-and middle-
income countries (LMICs). As a result of rapid urbanization in LMICs, a growing number of …
income countries (LMICs). As a result of rapid urbanization in LMICs, a growing number of …
[PDF][PDF] Fast principal-component analysis reveals convergent evolution of ADH1B in Europe and East Asia
Searching for genetic variants with unusual differentiation between subpopulations is an
established approach for identifying signals of natural selection. However, existing methods …
established approach for identifying signals of natural selection. However, existing methods …
[HTML][HTML] The evolving story of apolipoprotein L1 nephropathy: the end of the beginning
P Daneshpajouhnejad, JB Kopp, CA Winkler… - Nature Reviews …, 2022 - nature.com
Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were
identified in 2010 and are relatively common among individuals of sub-Saharan African …
identified in 2010 and are relatively common among individuals of sub-Saharan African …
APOL1 risk variants are strongly associated with HIV-associated nephropathy in black South Africans
AN Kasembeli, R Duarte, M Ramsay… - Journal of the …, 2015 - journals.lww.com
APOL1 variants are associated with HIV-associated nephropathy and FSGS in African
Americans. The prevalence of these variants in African populations with CKD in HIV-1 …
Americans. The prevalence of these variants in African populations with CKD in HIV-1 …
[HTML][HTML] Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
CR Swanepoel, MG Atta, VD D'Agati, MM Estrella… - Kidney international, 2018 - Elsevier
HIV-positive individuals are at increased risk for kidney disease, including HIV-associated
nephropathy, noncollapsing focal segmental glomerulosclerosis, immune-complex kidney …
nephropathy, noncollapsing focal segmental glomerulosclerosis, immune-complex kidney …
[HTML][HTML] Addressing Africa's pandemic puzzle: Perspectives on COVID-19 transmission and mortality in sub-Saharan Africa
Abstract To date, SARS-CoV-2 (the virus that causes COVID-19) has spread to almost every
region of the world, infecting millions and resulting in the deaths of hundreds of thousands of …
region of the world, infecting millions and resulting in the deaths of hundreds of thousands of …