Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies
Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors
Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) is an enzyme and a very omnipresent zinc
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
1, 3, 5‐Triazine: A versatile pharmacophore with diverse biological activities
S Singh, MK Mandal, A Masih, A Saha… - Archiv der …, 2021 - Wiley Online Library
Triazine and its derivatives have been the epicenter of chemotherapeutic molecules due to
their effective biological activities, such as antibacterial, fungicidal, antimalarial, anticancer …
their effective biological activities, such as antibacterial, fungicidal, antimalarial, anticancer …
Carbonic anhydrase IX: A tumor acidification switch in heterogeneity and chemokine regulation
The primary physiological process of respiration produces carbon dioxide (CO 2) that reacts
with water molecules which subsequently liberates bicarbonate (HCO–3) and protons …
with water molecules which subsequently liberates bicarbonate (HCO–3) and protons …
Carbonic Anhydrase Enzyme-MOFs Composite with a Superior Catalytic Performance to Promote CO2 Absorption into Tertiary Amine Solution
Carbonic anhydrase (CA) enzyme-based absorption technology for CO2 capture has been
intensively investigated. The main issue related to this novel technology is the activity and …
intensively investigated. The main issue related to this novel technology is the activity and …
Zeolitic imidazolate frameworks with different organic ligands as carriers for Carbonic anhydrase immobilization to promote the absorption of CO2 into tertiary amine …
Carbonic anhydrase (CA) enzyme-based absorption processes represent a promising
approach to flue gas CO 2 capture owing to their rapid absorption rates and low energy …
approach to flue gas CO 2 capture owing to their rapid absorption rates and low energy …
Interplay of carbon dioxide and peroxide metabolism in mammalian cells
R Radi - Journal of Biological Chemistry, 2022 - ASBMB
The carbon dioxide/bicarbonate (CO 2/HCO 3-) molecular pair is ubiquitous in mammalian
cells and tissues, mainly as a result of oxidative decarboxylation reactions that occur during …
cells and tissues, mainly as a result of oxidative decarboxylation reactions that occur during …
[HTML][HTML] Luminescent transition metal–organic frameworks: An emerging sensor for detecting biologically essential metal ions
The vast majority of the reported work on sensing metal ions is primarily based on
lanthanide containing luminescent MOFs and relatively few have so far addressed transition …
lanthanide containing luminescent MOFs and relatively few have so far addressed transition …
Structural annotation of human carbonic anhydrases
M Aggarwal, CD Boone, B Kondeti… - Journal of enzyme …, 2013 - Taylor & Francis
Carbonic anhydrases (CAs, EC 4.2. 1.1) are a family of metalloenzymes that catalyze the
reversible interconversion of CO2 and HCO3−. Of the 15 isoforms of human (h) α-CA, 12 are …
reversible interconversion of CO2 and HCO3−. Of the 15 isoforms of human (h) α-CA, 12 are …
Carbonic anhydrases as potential targets against neurovascular unit dysfunction in Alzheimer's disease and stroke
The Neurovascular Unit (NVU) is an important multicellular structure of the central nervous
system (CNS), which participates in the regulation of cerebral blood flow (CBF), delivery of …
system (CNS), which participates in the regulation of cerebral blood flow (CBF), delivery of …