Cancer accounts for numerous deaths each year, and it is one of the most common causes
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …

Microtubules, formed by α-and β-tubulin heterodimer, are considered as a major target to
prevent the proliferation of tumor cells. Microtubule-targeted agents have become …

Novel coumarin-indole derivatives were designed, synthesized and evaluated as tubulin
polymerization inhibitors targeting the colchicine binding site. Among these compounds …

A series of novel acridane-based tubulin polymerization inhibitors were designed,
synthesized, and bioevaluated as anticancer agents. The most potent compound NT-6 …

The synthesis and evaluation of small-molecule inhibitors of tubulin polymerization remains
a promising approach for the development of new therapeutic agents for cancer treatment …

Extensive preclinical studies have shown that colchicine-binding site inhibitors (CBSIs) are
promising drug candidates for cancer therapy. Although numerous CBSIs were generated …

Simple Summary The sabizabulin agent represses tumor cell growth, cell migration, and
colony formation, and induces cell death in HER2+ breast cancer models. Sabizabulin is …

Polymerization of tubulin dimers to form microtubules is one of the key events in cell
proliferation. The inhibition of this event has long been recognized as a potential treatment …

In previous studies, we synthesized different imidazo− pyrazoles 1 and 2 with interesting
anticancer, anti‐angiogenic and anti‐inflammatory activities. To further extend the structure …

A novel series of diphenylamine derivatives were designed and synthesized, and their
biological activities were evaluated. The anti-proliferative activities of the derivatives were …