Neurodegenerative diseases have two general characteristics that are so fundamental we
usually take them for granted. The first is that the pathology associated with the disease only …

Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic
lateral sclerosis, are a prominent class of neurological diseases currently without a cure …

Huntington's disease is caused by an abnormal polyglutamine expansion within the protein
huntingtin and is characterized by microscopic inclusion bodies of aggregated huntingtin …

Huntington's disease (HD) is a progressive, fatal neurological condition caused by an
expansion of CAG (glutamine) repeats in the coding region of the Huntington gene. To date …

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative
disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral …

Huntington's disease (HD) is the most common inherited neurodegenerative disease and is
characterized by uncontrolled excessive motor movements and cognitive and emotional …

Huntington's disease (HD) is characterized by the selective loss of striatal projection
neurons. In early stages of HD, neurodegeneration preferentially occurs in the lateral globus …

The mechanism that controls the selective vulnerability of striatal neurons in Huntington's
disease is unclear. Brain-derived neurotrophic factor (BDNF) protects striatal neurons and is …

The corticostriatal pathway provides most of the excitatory glutamatergic input into the
striatum and it plays an important role in the development of the phenotype of Huntington's …

Huntington's disease (HD) is an inherited, autosomal dominant, neurodegenerative disorder
characterized by involuntary choreiform movements, cognitive decline and a progressive …