Metastasis involves several distinct steps, including one in which the tumor cell, after entry
into the bloodstream, comes to rest in a capillary located at the distant site where a …

A volume of data that has accumulated for over a century has suggested that fibrin may
facilitate the persistence and progression of malignancy. Techniques that have been …

Background Small cell lung cancer (SCLC) is a chemotherapy‐responsive tumor type but
most patients ultimately experience disease progression. SCLC is associated with …

Background. A positive influence of anticoagulant treatment in small cell lung cancer (SCLC)
has been sug gested by experimental and clinical data. Methods. In a multicenter clinical …

Clinical and experimental studies have suggested that unfractionated heparin (UFH) effects
malignancy progression. We reviewed all published clinical reports concerning the effects of …

Fibrin, one of the components of the extracellular matrix (ECM), acts as a transport barrier
within the core of tumors by constricting the blood vessels and forming clots, leading to poor …

Coagulation disorders are a common problem in neoplastic patients and many factors
contribute to increase the risk of thromboembolic events in these patients. An …

The purpose of this review is to demonstrate the potential for development of coagulation-
reactive drugs for experimental cancer treatment. Improved cancer outcome has been …

Elevated interstitial fluid pressure and solid stress within tumors contribute to poor
intratumoral distribution of nanomedicine. In this study, we hypothesized that the presence of …

The interaction between malignant cell growth and the coagulation and fibrinolysis system
has been a well known phenomenon for decades. During recent years, this area of research …