Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one
neutron to a molecule. Despite being a subtle change, this structural modification, known as …

Our incomplete understanding of the causes and pathways involved in the onset and
progression of multiple sclerosis (MS) limits our ability to effectively treat this complex …

The genetic make-up of an individual contributes to the susceptibility and response to viral
infection. Although environmental, clinical and social factors have a role in the chance of …

Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …

Psoriasis is a chronic inflammatory disease characterised by sharply demarcated
erythematous and scaly skin lesions accompanied by systemic manifestations. Classified by …

Abstract The UK Biobank Exome Sequencing Consortium (UKB-ESC) is a private–public
partnership between the UK Biobank (UKB) and eight biopharmaceutical companies that …

The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2
(SARS-CoV-2) poses an unprecedented challenge to humanity. SARS-CoV-2 infections …

Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …

Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …