Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …

Influenza virus (IFV) causes periodic global influenza pandemics, resulting in substantial
socioeconomic loss and burden on medical facilities. Yearly variation in the effectiveness of …

Bunyaviruses are a large family of segmented RNA viruses which, like influenza virus, use a
cap-snatching mechanism for transcription whereby short capped primers derived by …

It is generally recognised that novel antiviral drugs, less prone to resistance, would be a
desirable alternative to current drug options in order to be able to treat potentially serious …

Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from
cellular transcripts by a 'cap-snatching'mechanism. Here, we report the crystal structure and …

Coronaviruses (CoVs) cause numerous diseases, including Middle East respiratory
syndrome and severe acute respiratory syndrome, generating significant health-related and …

Proteins belonging to PD-(D/E) XK phosphodiesterases constitute a functionally diverse
superfamily with representatives involved in replication, restriction, DNA repair and tRNA …

Emerging influenza viruses are a serious threat to human health because of their pandemic
potential. A promising target for the development of novel anti-influenza therapeutics is the …

Background The amphibian, non-vascular, gametophyte-dominant, bio-indicator class,
bryophytes; with their wide ranges of habitat have attained importance due to their promising …

Influenza viruses have been responsible for the largest pandemics in the previous century.
Although vaccination and prophylactic antiviral therapeutics are the primary defense against …