[HTML][HTML] Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment

S Peerapornratana, CL Manrique-Caballero… - Kidney international, 2019 - Elsevier
Sepsis-associated acute kidney injury (S-AKI) is a frequent complication of the critically ill
patient and is associated with unacceptable morbidity and mortality. Prevention of S-AKI is …

Current concepts and advances in biomarkers of acute kidney injury

Y Wen, CR Parikh - Critical reviews in clinical laboratory sciences, 2021 - Taylor & Francis
Despite advancements in standardizing the criteria for acute kidney injury (AKI), its definition
remains based on changes in serum creatinine and urinary output that do not specifically …

[HTML][HTML] Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference

M Ostermann, R Bellomo, EA Burdmann, K Doi… - Kidney international, 2020 - Elsevier
In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline on the
classification and management of acute kidney injury (AKI). The guideline was derived from …

[HTML][HTML] Acute kidney injury in SARS-CoV-2 infected patients

V Fanelli, M Fiorentino, V Cantaluppi, L Gesualdo… - Critical Care, 2020 - Springer
Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the
pathogen responsible of atypical pneumonia that has affected more than 330,000 people …

Paradigms of acute kidney injury in the intensive care setting

JA Kellum, JR Prowle - Nature Reviews Nephrology, 2018 - nature.com
Acute kidney injury (AKI) is a heterogeneous clinical syndrome that has multiple aetiologies,
variable pathogenesis and diverse outcomes. However, these heterogeneities are not …

Recovery after acute kidney injury

JA Kellum, FE Sileanu, A Bihorac… - American journal of …, 2017 - atsjournals.org
Rationale: Little is known about how acute kidney injury (AKI) resolves, and whether
patterns of reversal of renal dysfunction differ among patients with respect to ultimate …

Inflammation in AKI: current understanding, key questions, and knowledge gaps

H Rabb, MD Griffin, DB McKay… - Journal of the …, 2016 - journals.lww.com
Inflammation is a complex biologic response that is essential for eliminating microbial
pathogens and repairing tissue after injury. AKI associates with intrarenal and systemic …

Biomarkers in acute kidney injury–pathophysiological basis and clinical performance

EV Schrezenmeier, J Barasch, K Budde… - Acta …, 2017 - Wiley Online Library
Various biomarkers of acute kidney injury (AKI) have been discovered and characterized in
the recent past. These molecules can be detected in urine or blood and signify structural …

Biomarkers of drug-induced kidney toxicity

BR Griffin, S Faubel, CL Edelstein - Therapeutic drug monitoring, 2019 - journals.lww.com
Blood urea nitrogen and serum creatinine are imperfect markers of kidney function because
they are influenced by many renal and nonrenal factors independent of kidney function. A …

[HTML][HTML] Biomarkers of acute kidney injury: the pathway from discovery to clinical adoption

K Kashani, W Cheungpasitporn… - Clinical Chemistry and …, 2017 - degruyter.com
Acute kidney injury (AKI) is a common complication of critical illnesses and has a significant
impact on outcomes, including mortality and morbidities. Unfortunately, apart from …