Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide and is often associated with aspects of metabolic syndrome. Despite its …
worldwide and is often associated with aspects of metabolic syndrome. Despite its …
The liver as an endocrine organ—linking NAFLD and insulin resistance
MJ Watt, PM Miotto, W De Nardo… - Endocrine …, 2019 - academic.oup.com
The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …
The mechanisms of lysophosphatidylcholine in the development of diseases
Lysophosphatidylcholine (LPC) is the main component of oxidatively damaged low-density
lipoprotein (oxLDL). LPC originates from the cleavage of phosphatidylcholine by …
lipoprotein (oxLDL). LPC originates from the cleavage of phosphatidylcholine by …
[PDF][PDF] Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance
Plasma concentrations of amino acids (AAs), in particular, branched chain AAs (BCAAs), are
often found increased in nonalcoholic fatty liver disease (NAFLD); however, if this is due to …
often found increased in nonalcoholic fatty liver disease (NAFLD); however, if this is due to …
The impact of insulin resistance on the kidney and vasculature
F Artunc, E Schleicher, C Weigert, A Fritsche… - Nature Reviews …, 2016 - nature.com
Insulin resistance is a systemic disorder that affects many organs and insulin-regulated
pathways. The disorder is characterized by a reduced action of insulin despite increased …
pathways. The disorder is characterized by a reduced action of insulin despite increased …
Relationship of serum trimethylamine N-oxide (TMAO) levels with early atherosclerosis in humans
E Randrianarisoa, A Lehn-Stefan, X Wang, M Hoene… - Scientific reports, 2016 - nature.com
Abstract Circulating trimethylamine N-Oxide (TMAO) levels predict cardiovascular disease
(CVD), possibly by impacting on cholesterol metabolism and oxidative stress. Because …
(CVD), possibly by impacting on cholesterol metabolism and oxidative stress. Because …
A systematic review: burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; should we care?
Background Non-alcoholic fatty liver disease (NAFLD) is an emerging disease and a
leading cause of chronic liver disease. The prevalence in the general population is …
leading cause of chronic liver disease. The prevalence in the general population is …
Plasma lipidomic profiling and risk of type 2 diabetes in the PREDIMED trial
C Razquin, E Toledo, CB Clish, M Ruiz-Canela… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE Specific lipid molecular changes leading to type 2 diabetes (T2D) are largely
unknown. We assessed lipidome factors associated with future occurrence of T2D in a …
unknown. We assessed lipidome factors associated with future occurrence of T2D in a …
TMAVA, a metabolite of intestinal microbes, is increased in plasma from patients with liver steatosis, inhibits γ-butyrobetaine hydroxylase, and exacerbates fatty liver in …
M Zhao, L Zhao, X Xiong, Y He, W Huang, Z Liu, L Ji… - Gastroenterology, 2020 - Elsevier
Background & Aims Nonalcoholic fatty liver disease is characterized by excessive hepatic
accumulation of triglycerides. We aimed to identify metabolites that differ in plasma of …
accumulation of triglycerides. We aimed to identify metabolites that differ in plasma of …
Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?
Growing epidemiological evidence suggests that nonalcoholic fatty liver disease (NAFLD) is
an early predictor of and determinant for the development of type 2 diabetes and other …
an early predictor of and determinant for the development of type 2 diabetes and other …