Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Structural biology of SARS-CoV-2 and implications for therapeutic development

H Yang, Z Rao - Nature Reviews Microbiology, 2021 - nature.com
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for …

Antibody-mediated neutralization of SARS-CoV-2

H Gruell, K Vanshylla, T Weber, CO Barnes, C Kreer… - Immunity, 2022 - cell.com
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

C Sun, C Xie, GL Bu, LY Zhong, MS Zeng - Signal Transduction and …, 2022 - nature.com
The persistent COVID-19 pandemic since 2020 has brought an enormous public health
burden to the global society and is accompanied by various evolution of the virus genome …

[PDF][PDF] The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants

C Liu, D Zhou, R Nutalai, HME Duyvesteyn… - Cell Host & Microbe, 2022 - cell.com
Summary Alpha-B. 1.1. 7, Beta-B. 1.351, Gamma-P. 1, and Delta-B. 1.617. 2 variants of
SARS-CoV-2 express multiple mutations in the spike protein (S). These may alter the …

Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection

YC Hwang, RM Lu, SC Su, PY Chiang, SH Ko… - Journal of Biomedical …, 2022 - Springer
Abstract The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public
health crisis that demands the timely creation of new therapeutics and viral detection. Owing …

Passive immunotherapy against SARS-CoV-2: from plasma-based therapy to single potent antibodies in the race to stay ahead of the variants

WR Strohl, Z Ku, Z An, SF Carroll, BA Keyt, LM Strohl - BioDrugs, 2022 - Springer
The COVID-19 pandemic is now approaching 2 years old, with more than 440 million people
infected and nearly six million dead worldwide, making it the most significant pandemic …

A third dose of inactivated vaccine augments the potency, breadth, and duration of anamnestic responses against SARS-CoV-2

Z Jia, K Wang, M Xie, J Wu, Y Hu, Y Zhou… - Protein & …, 2024 - academic.oup.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) has lasted for more than four years …

[HTML][HTML] Differential antibody response to inactivated COVID-19 vaccines in healthy subjects

J Zhang, S Xing, D Liang, W Hu, C Ke, J He… - Frontiers in cellular …, 2021 - frontiersin.org
The appearance and magnitude of the immune response and the related factors correlated
with SARS-CoV-2 vaccination need to be defined. Here, we enrolled a prospective cohort of …

Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection

Y Guo, G Zhang, Q Yang, X Xie, Y Lu, X Cheng… - Nature …, 2023 - nature.com
Abstract The SARS-CoV-2 Omicron variant evades most currently approved neutralizing
antibodies (nAbs) and caused drastic decrease of plasma neutralizing activity elicited by …