Recent insights into the mechanisms of anaphylaxis

WW Stevens, M Kraft, SC Eisenbarth - Current opinion in immunology, 2023 - Elsevier
Anaphylaxis is an acute life-threatening systemic allergic reaction that can have a wide
range of clinical manifestations. The most common triggers for anaphylaxis include food …

[HTML][HTML] How to define and manage low-risk drug allergy labels

AM Copaescu, L Li, KG Blumenthal… - The Journal of Allergy and …, 2024 - Elsevier
Risk stratification in drug allergy implies that specific risk categories (eg, low, moderate, and
high) classify historical drug hypersensitivity reactions. These risk categories can be based …

[HTML][HTML] Ketoprofen, lysine and gabapentin co-crystal magnifies synergistic efficacy and tolerability of the constituent drugs: Pre-clinical evidences towards an …

A Aramini, G Bianchini, S Lillini, M Tomassetti… - Biomedicine & …, 2023 - Elsevier
Chronic pain is an enormous public health concern, and its treatment is still an unmet
medical need. Starting from data highlighting the promising effects of some nonsteroidal anti …

Complement Receptor C3aR1 Contributes to Paclitaxel-Induced Peripheral Neuropathic Pain in Mice and Rats

J Xu, P Huang, B Bie, Y Dai, S Ben-Salem… - The Journal of …, 2023 - journals.aai.org
Cancer chemotherapy-induced neuropathic pain is a devastating pain syndrome without
effective therapies. We previously reported that rats deficient in complement C3, the central …

[HTML][HTML] Inhibition of C5aR1 as a promising approach to treat taxane-induced neuropathy

C Cristiano, C Giorgio, P Cocchiaro, S Boccella… - Cytokine, 2023 - Elsevier
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of several
antitumor agents resulting in progressive and often irreversible damage of peripheral …

Bergenin ameliorates chemotherapy-induced neuropathic pain in rats by modulating TRPA1/TRPV1/NR2B signalling

D Chouhan, O Ummadisetty, N Verma… - International …, 2023 - Elsevier
Chemotherapy-induced neuropathic pain (CINP) is one of the most prominent and
incapacitating complication associated with chemotherapeutic regimens. The exact …

Therapeutics for chemotherapy-induced peripheral neuropathy: approaches with natural compounds from traditional eastern medicine

G Chung, SK Kim - Pharmaceutics, 2022 - mdpi.com
Chemotherapy-induced peripheral neuropathy (CIPN) often develops in patients with cancer
treated with commonly used anti-cancer drugs. The symptoms of CIPN can occur acutely …

[HTML][HTML] Targeting complement C5a to improve radiotherapy sensitivity in non-small cell lung cancer

M Yuan, C Wang, Y Wu, L Qiao, G Deng… - Translational Lung …, 2023 - ncbi.nlm.nih.gov
Background Tumor local and distant relapse recurrence after radiotherapy (RT) is one of the
critical factors leading to poor prognosis. The effective antitumor effects of RT are dependent …

Emerging approaches for the management of chemotherapy-induced peripheral neuropathy (CIPN): Therapeutic potential of the C5a/C5aR Axis

MC Spera, MC Cesta, M Zippoli, G Varrassi… - Pain and Therapy, 2022 - Springer
Chemotherapy-induced peripheral neuropathy (CIPN) is the most common neurologic
complication of chemotherapy, resulting in symptoms like pain, sensory loss, and numbness …

Molecular and Cellular Involvement in CIPN

H Kacem, A Cimini, M d'Angelo, V Castelli - Biomedicines, 2024 - mdpi.com
Many anti-cancer drugs, such as taxanes, platinum compounds, vinca alkaloids, and
proteasome inhibitors, can cause chemotherapy-induced peripheral neuropathy (CIPN) …