Repurposing psychotropic agents for viral disorders: beyond COVID

SR Golden, DL Rosenstein, T Belhorn… - ASSAY and Drug …, 2021 - liebertpub.com
Recent reports have highlighted the possible role of the antipsychotic chlorpromazine and
the antidepressant fluvoxamine as anti-coronavirus disease 2019 (COVID-19) agents. The …

Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity

ML Saiz, ML De Diego, D López-García… - Clinical …, 2021 - Springer
Background SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) and neuropilin-
1 (NRP1) receptors for entry into cells, and the serine protease TMPRSS2 for S protein …

Base de Datos para la Investigación Farmacoepidemiológica en Atención Primaria (BIFAP): A data resource for pharmacoepidemiology in Spain

MA Maciá‐Martínez, M Gil, C Huerta… - … and Drug Safety, 2020 - Wiley Online Library
Abstract Purpose Base de Datos para la Investigación Farmacoepidemiológica en Atención
Primaria (BIFAP) is a population based database administered by the AEMPS (Spanish …

Valproic acid and its amidic derivatives as new antivirals against alphaherpesviruses

S Andreu, I Ripa, R Bello-Morales, JA López-Guerrero - Viruses, 2020 - mdpi.com
Herpes simplex viruses (HSVs) are neurotropic viruses with broad host range whose
infections cause considerable health problems in both animals and humans. In fact, 67% of …

The valproic acid derivative valpromide inhibits pseudorabies virus infection in swine epithelial and mouse neuroblastoma cell lines

S Andreu, I Ripa, B Praena, JA López-Guerrero… - Viruses, 2021 - mdpi.com
Pseudorabies virus (PRV) infection of swine can produce Aujeszky's disease, which causes
neurological, respiratory, and reproductive symptoms, leading to significant economic losses …

Exposure to valproic acid is associated with less pulmonary infiltrates and improvements in diverse clinical outcomes and laboratory parameters in patients …

J Collazos, P Domingo, N Fernández-Araujo… - PLoS …, 2022 - journals.plos.org
Background Valproic acid (VPA) has shown beneficial effects in vitro against SARS-CoV-2
infection, but no study has analyzed its efficacy in the clinical setting. Methods This …

Inhibition of Human Coronaviruses by Combinations of Host-Targeted and Direct-Acting Antivirals

P de León, R Cañas-Arranz, MJ Bustos… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Antiviral compounds targeting cellular metabolism are part of the therapeutic arsenal to
control the spread of virus infection, either as sole treatment or in combination with direct …

Progress of Research into Novel Drugs and Potential Drug Targets against Porcine Pseudorabies Virus

M Zhou, M Abid, S Cao, S Zhu - Viruses, 2022 - mdpi.com
Pseudorabies virus (PRV) is the causative agent of pseudorabies (PR), infecting most
mammals and some birds. It has been prevalent around the world and caused huge …

[HTML][HTML] Valproic acid could help in the fight against COVID-19: A case–control study

O Moreno-Pérez, E Merino, JM Ramos, JC Rodríguez… - Neurologia, 2022 - Elsevier
Objective There is early evidence about Valproic acid (VPA) antiviral effect. Our aim was to
investigate the incidence and severity of SARS-CoV-2 infection in VPA users as compared …

BIFAP Program: A Data Resource for Pharmacoepidemiological Research in Spain

M Gil, MA Maciá, J Bonis, C Huerta… - Databases for …, 2021 - Springer
BIFAP includes information routinely collected by primary care physicians (PCPs) in their
practices (real-world data). In 2018, the BIFAP database included anonymized and …