Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction.
Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the …

Introduction Biomarkers can be useful for identifying or ruling out sepsis, identifying patients
who may benefit from specific therapies or assessing the response to therapy. Methods We …

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

Background Vitamin C is an essential water-soluble nutrient which cannot be synthesised or
stored by humans. It is a potent antioxidant with anti-inflammatory and immune-supportive …

Purpose Using latent class analysis (LCA), we have consistently identified two distinct
subphenotypes in four randomized controlled trial cohorts of ARDS. One subphenotype has …

Background Parenterally administered ascorbic acid modulates sepsis-induced
inflammation and coagulation in experimental animal models. The objective of this …

Background: The inflammatory reaction is the main cause of acute respiratory distress
syndrome and multiple organ failure in patients with Coronavirus disease 2019, especially …

Sepsis is among the most common causes of death in hospitals. It arises from the host
response to infection. Currently, diagnosis relies on nonspecific physiological criteria and …

Background Epigenetic clocks can track both chronological age (cAge) and biological age
(bAge). The latter is typically defined by physiological biomarkers and risk of adverse health …

Because of their extensive wounds, burn patients are chronically exposed to inflammatory
mediators. Thus, burn patients, by definition, already have “systemic inflammatory response …