Substrates for embryonic stem cell culture are typified by poorly defined xenogenic, whole
proteins or cellular components that are difficult and expensive to generate, characterize …

Chicken embryonic stem cells (cESCs) isolated from the egg at the stage X hold great
promise for cell therapy, tissue engineering, pharmaceutical, and biotechnological …

De novo variants in the NaV1. 2 voltage‐gated sodium channel gene SCN2A are among the
major causes of developmental and epileptic encephalopathies (DEE). Based on their …

Background and Purpose Hyperpolarization‐activated cyclic nucleotide‐gated (HCN)
channels are encoded by four genes (HCN1–4) with distinct biophysical properties and …

Stem cell transplantation is an advanced medical technology, which brings hope for the
treatment of some difficult diseases in the clinic. Attributed to its self-renewal and differential …

Background Mature primary neuronal cultures are an important model of the nervous
system, but limited scalability has been a major challenge in their use for drug discovery of …

Background Transcription factor-based forward programming enables the efficient
generation of forebrain excitatory and inhibitory neurons from human pluripotent stem cells …

Background Neural differentiation from embryonic stem cells (ESCs) is an excellent model
for elucidating the key mechanisms involved in neurogenesis, and also provides an …

The neural differentiation of mouse embryonic stem cells (mESCs) is a potential tool for
elucidating the key mechanisms involved in neurogenesis and potentially aid in …

Ketamine is a widely used general anesthetic and has been reported to demonstrate
neurotoxicity and neuroprotection. Investigation into the regulatory mechanism of ketamine …