Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …

Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its
clinical significance, there are still significant gaps in our understanding of pathogenic and …

INTRODUCTION Clinical outcomes of human severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus …

Macrophages help defend the host against Mycobacterium tuberculosis (Mtb), the major
cause of tuberculosis (TB). Once phagocytized, Mtb resists killing by macrophages …

Abstract The bacterium Mycobacterium tuberculosis (Mtb) causes tuberculosis and is
responsible for more human mortality than any other single pathogen. Progression to active …

Globally, autosomal recessive IFNAR1 deficiency is a rare inborn error of immunity
underlying susceptibility to live attenuated vaccine and wild-type viruses. We report seven …

Mycobacterium tuberculosis (Mtb) triggers distinct changes in macrophages, resulting in the
formation of lipid droplets that serve as a nutrient source. We discover that Mtb promotes …

Summary Mycobacterium tuberculosis (Mtb) causes 1.6 million deaths annually. Active
tuberculosis correlates with a neutrophil-driven type I interferon (IFN) signature, but the …

Blood transcriptomics analysis of tuberculosis has revealed an interferon-inducible gene
signature that diminishes in expression after successful treatment; this promises improved …

Despite major strides in personalized genomics, it remains poorly understood why
neurodegenerative diseases occur in only a fraction of individuals with a genetic …