Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically
available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective …

Eosinophils are capable of generating eicosanoid derivatives of arachidonic acid by means
of cyclooxygenase and the 5-and 15-lipoxygenase (LO) pathways. Moreover, eosinophils …

We examined the effect of p38 mitogen‐activated protein kinase (MAPK) inhibitors in models
of nociception and correlated this effect with localization and expression levels of p38 MAPK …

Lipoxygenase (5‐LO) is the key enzyme in the biosynthesis of proinflammatory leukotrienes.
Here, we demonstrate that extracellular signal‐regulated kinases (ERKs) can phosphorylate …

Antagonist studies show that spinal p38 mitogen‐activated protein kinase plays a crucial
role in spinal sensitization. However, there are two p38 isoforms found in spinal cord and the …

Stable expression of human groups IIA and X secreted phospholipases A 2 (hGIIA and hGX)
in CHO-K1 and HEK293 cells leads to serum-and interleukin-1β-promoted arachidonate …

J. Neurochem.(2010) 112, 1249–1260. Abstract Our previous works have elucidated that the
12‐lipoxygenase pathway is directly implicated in glutamate‐induced neural cell death, and …

Cytosolic phospholipase A2 (cPLA2) is a Ca2+‐dependent enzyme that mediates agonist‐
dependent arachidonic acid release in most cell types. Arachidonic acid can then be …

Extracellular signal-regulated kinase (ERK) is a versatile protein kinase, which has been
implicated in signaling numerous biological functions ranging from embryonic development …

Eosinophils are the main source of the cysteinyl leukotrienes, LTC4/D4/E4, which are lipid
mediators that play major roles in the pathogenesis of asthma and other forms of allergic …