Radiopharmaceutical therapy in cancer: clinical advances and challenges

G Sgouros, L Bodei, MR McDevitt… - Nature reviews Drug …, 2020 - nature.com
Radiopharmaceutical therapy (RPT) is emerging as a safe and effective targeted approach
to treating many types of cancer. In RPT, radiation is systemically or locally delivered using …

Active targeting schemes for nanoparticle systems in cancer therapeutics

JD Byrne, T Betancourt, L Brannon-Peppas - Advanced drug delivery …, 2008 - Elsevier
The objective of this review is to outline current major cancer targets for nanoparticle
systems and give insight into the direction of the field. The major targeting strategies that …

68Ga-and 177Lu-labeled PSMA I&T: optimization of a PSMA-targeted theranostic concept and first proof-of-concept human studies

M Weineisen, M Schottelius, J Simecek… - Journal of Nuclear …, 2015 - Soc Nuclear Med
On the basis of the high and consistent expression of prostate-specific membrane antigen
(PSMA) in metastatic prostate cancer (PC), the goal of this study was the development …

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt (IV) prodrug-PLGA–PEG nanoparticles

S Dhar, FX Gu, R Langer… - Proceedings of the …, 2008 - National Acad Sciences
Cisplatin is used to treat a variety of tumors, but dose limiting toxicities or intrinsic and
acquired resistance limit its application in many types of cancer including prostate. We report …

Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature

SS Chang, VE Reuter, WDW Heston, NH Bander… - Cancer research, 1999 - AACR
Prostate-specific membrane antigen (PSMA) is a type II integral membrane glycoprotein that
was initially characterized by the monoclonal antibody (mAb) 7E11. PSMA is highly …

Expression of prostate-specific membrane antigen (PSMA) on biopsies is an independent risk stratifier of prostate cancer patients at time of initial diagnosis

MC Hupe, C Philippi, D Roth, C Kümpers… - Frontiers in …, 2018 - frontiersin.org
Background: Stratifying prostate cancer (PCa) patients into risk groups at time of initial
diagnosis enabling a risk-adapted disease management is still a major clinical challenge …

Prostate-specific membrane antigen expression is greatest in prostate adenocarcinoma and lymph node metastases

SD Sweat, A Pacelli, GP Murphy, DG Bostwick - Urology, 1998 - Elsevier
Objectives. Prostate-specific membrane antigen (PSMA) is an integral membrane protein
highly specific for the prostate. PSMA may be clinically useful for predicting outcome in …

Using PSMA imaging for prognostication in localized and advanced prostate cancer

MJ Roberts, T Maurer, M Perera, M Eiber… - Nature Reviews …, 2023 - nature.com
The use of prostate-specific membrane antigen (PSMA)-directed applications in modern
prostate cancer management has evolved rapidly over the past few years, helping to …

Glu-ureido–based inhibitors of prostate-specific membrane antigen: lessons learned during the development of a novel class of low-molecular-weight theranostic …

K Kopka, M Benešová, C Bařinka… - Journal of Nuclear …, 2017 - Soc Nuclear Med
In recent years, several radioligands targeting prostate-specific membrane antigen (PSMA)
have been clinically introduced as a new class of theranostic radiopharmaceuticals for the …

[HTML][HTML] Overview of prostate-specific membrane antigen

SS Chang - Reviews in urology, 2004 - ncbi.nlm.nih.gov
Efforts to evaluate and discover diagnostic and therapeutic markers for prostate cancer
continue. One of these, prostate-specific membrane antigen (PSMA), a transmembrane …