The current unidimensional paradigm of kidney disease detection is incompatible with the
complexity and heterogeneity of renal pathology. The diagnosis of kidney disease has …

Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney
and is the most abundant protein in normal urine. The function of uromodulin remains …

African Americans have a heightened risk of developing chronic and end-stage kidney
disease, an association that is largely attributed to two common genetic variants, termed G1 …

Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a nonapoptotic
form of regulated cell death that has been implicated in maladaptive renal repair in mice and …

Chronic kidney disease (CKD) represents a leading cause of death in the United States.
There is no cure for this disease, with current treatment strategies relying on blood pressure …

Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Biomarkers of diverse pathophysiologic mechanisms may improve risk stratification for
incident or progressive diabetic kidney disease (DKD) in persons with type 2 diabetes. To …

Although diabetes is mainly diagnosed based on elevated glucose levels, dyslipidemia is
also observed in these patients. Chronic kidney disease (CKD), a frequent occurrence in …

Biology has taught us that a protein as abundantly made and conserved among species as
Tamm–Horsfall protein (THP or uromodulin) cannot just be a waste product serving no …

Over the past decade, genome-wide association studies (GWAS) have considerably
improved our understanding of the genetic basis of kidney function and disease. Population …