[HTML][HTML] The JAK-STAT pathway at 30: Much learned, much more to do
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
Decoding type I and III interferon signalling during viral infection
EV Mesev, RA LeDesma, A Ploss - Nature microbiology, 2019 - nature.com
Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
Activation of the RIG-I-like receptors, retinoic-acid inducible gene I (RIG-I) and melanoma
differentiation-associated protein 5 (MDA5), establishes an antiviral state by upregulating …
differentiation-associated protein 5 (MDA5), establishes an antiviral state by upregulating …
ISG15 in antiviral immunity and beyond
YC Perng, DJ Lenschow - Nature Reviews Microbiology, 2018 - nature.com
The host response to viral infection includes the induction of type I interferons and the
subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein …
subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein …
ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins
Exosomes are vesicles secreted to the extracellular environment through fusion with the
plasma membrane of specific endosomes called multivesicular bodies (MVB) and mediate …
plasma membrane of specific endosomes called multivesicular bodies (MVB) and mediate …
Disorders of ubiquitylation: unchained inflammation
Ubiquitylation is an essential post-translational modification that regulates intracellular
signalling networks by triggering proteasomal substrate degradation, changing the activity of …
signalling networks by triggering proteasomal substrate degradation, changing the activity of …
Differential activation of the transcription factor IRF1 underlies the distinct immune responses elicited by type I and type III interferons
Type I and III interferons (IFNs) activate similar downstream signaling cascades, but unlike
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …
The molecular basis for differential type I interferon signaling
G Schreiber - Journal of Biological Chemistry, 2017 - ASBMB
Type I interferons (IFN-1) are cytokines that affect the expression of thousands of genes,
resulting in profound cellular changes. IFN-1 activates the cell by dimerizing its two-receptor …
resulting in profound cellular changes. IFN-1 activates the cell by dimerizing its two-receptor …
Extracellular ISG15 signals cytokine secretion through the LFA-1 integrin receptor
CD Swaim, AF Scott, LA Canadeo, JM Huibregtse - Molecular cell, 2017 - cell.com
ISG15 is a ubiquitin-like protein that functions in innate immunity both as an intracellular
protein modifier and as an extracellular signaling molecule that stimulates IFN-γ secretion …
protein modifier and as an extracellular signaling molecule that stimulates IFN-γ secretion …
ISG15 and ISGylation in human diseases
O Mirzalieva, M Juncker, J Schwartzenburg, S Desai - Cells, 2022 - mdpi.com
Type I Interferons (IFNs) induce the expression of> 500 genes, which are collectively called
ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon …
ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon …