Reverse engineering and identification in systems biology: strategies, perspectives and challenges

AF Villaverde, JR Banga - Journal of the Royal Society …, 2014 - royalsocietypublishing.org
The interplay of mathematical modelling with experiments is one of the central elements in
systems biology. The aim of reverse engineering is to infer, analyse and understand …

Input design for active fault diagnosis

TAN Heirung, A Mesbah - Annual Reviews in Control, 2019 - Elsevier
Reliably diagnosing faults and malfunctions has become increasingly challenging in
modern technical systems because of their growing complexity as well as increasingly …

Maximizing the information content of experiments in systems biology

J Liepe, S Filippi, M Komorowski… - PLoS computational …, 2013 - journals.plos.org
Our understanding of most biological systems is in its infancy. Learning their structure and
intricacies is fraught with challenges, and often side-stepped in favour of studying the …

[图书][B] Feedback control in systems biology

C Cosentino, D Bates - 2011 - books.google.com
Like engineering systems, biological systems must also operate effectively in the presence
of internal and external uncertainty—such as genetic mutations or temperature changes, for …

A review of active learning approaches to experimental design for uncovering biological networks

Y Sverchkov, M Craven - PLoS computational biology, 2017 - journals.plos.org
Various types of biological knowledge describe networks of interactions among elementary
entities. For example, transcriptional regulatory networks consist of interactions among …

Machine learning for real-time diagnostics of cold atmospheric plasma sources

D Gidon, X Pei, AD Bonzanini… - … on Radiation and …, 2019 - ieeexplore.ieee.org
Real-time diagnostics of cold atmospheric plasma (CAP) sources can be challenging due to
the requirement for expensive equipment and complicated analysis. Data analytics that rely …

Practical limits for reverse engineering of dynamical systems: a statistical analysis of sensitivity and parameter inferability in systems biology models

K Erguler, MPH Stumpf - Molecular BioSystems, 2011 - pubs.rsc.org
The size and complexity of cellular systems make building predictive models an extremely
difficult task. In principle dynamical time-course data can be used to elucidate the structure …

Programmable intratumoral drug delivery to breast cancer using wireless bioelectronic device with electrochemical actuation

M Souri, S Elahi, M Soltani - Expert Opinion on Drug Delivery, 2024 - Taylor & Francis
Objective Breast cancer is a global health concern that demands attention. In our
contribution to addressing this disease, our study focuses on investigating a wireless micro …

[PDF][PDF] Identifiability of large nonlinear biochemical networks

AF Villaverde, A Barreiro - MATCH Commun. Math. Comput …, 2016 - researchgate.net
Dynamic models formulated as a set of ordinary differential equations provide a detailed
description of the time-evolution of a system. Such models of (bio) chemical reaction …

Validation-based model selection for 13C metabolic flux analysis with uncertain measurement errors

N Sundqvist, N Grankvist, J Watrous… - PLOS Computational …, 2022 - journals.plos.org
Accurate measurements of metabolic fluxes in living cells are central to metabolism research
and metabolic engineering. The gold standard method is model-based metabolic flux …