RNA-binding proteins in human genetic disease
RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …
Identification of RNA–protein interaction networks using PAR‐CLIP
All mRNA molecules are subject to some degree of post‐transcriptional gene regulation
(PTGR) involving sequence‐dependent modulation of splicing, cleavage and …
(PTGR) involving sequence‐dependent modulation of splicing, cleavage and …
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability
RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying
these global interactions remain poorly understood. We elucidated regulatory mechanisms …
these global interactions remain poorly understood. We elucidated regulatory mechanisms …
LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR
The function of the vast majority of mammalian long noncoding (lnc) RNAs remains
unknown. Here, analysis of a highly abundant mammalian lncRNA, OIP5-AS1, known as …
unknown. Here, analysis of a highly abundant mammalian lncRNA, OIP5-AS1, known as …
UNR/CSDE1 drives a post-transcriptional program to promote melanoma invasion and metastasis
RNA binding proteins (RBPs) modulate cancer progression through poorly understood
mechanisms. Here we show that the RBP UNR/CSDE1 is overexpressed in melanoma …
mechanisms. Here we show that the RBP UNR/CSDE1 is overexpressed in melanoma …
Deciphering the mRNP code: RNA-bound determinants of post-transcriptional gene regulation
NH Gehring, E Wahle, U Fischer - Trends in biochemical sciences, 2017 - cell.com
Eukaryotic cells determine the final protein output of their genetic program not only by
controlling transcription but also by regulating the localization, translation and turnover rates …
controlling transcription but also by regulating the localization, translation and turnover rates …
Eukaryotic mRNA decay: methodologies, pathways, and links to other stages of gene expression
Abstract mRNA concentration depends on the balance between transcription and
degradation rates. On both sides of the equilibrium, synthesis and degradation show …
degradation rates. On both sides of the equilibrium, synthesis and degradation show …
Mechanisms coordinating ELAV/Hu mRNA regulons
LE Simone, JD Keene - Current opinion in genetics & development, 2013 - Elsevier
The 5′ and 3′ untranslated regions (UTRs) of messenger RNAs (mRNAs) function as
platforms that can determine the fate of each mRNA individually and in aggregate. Multiple …
platforms that can determine the fate of each mRNA individually and in aggregate. Multiple …
RNA localization: Making its way to the center stage
A Chin, E Lécuyer - Biochimica et Biophysica Acta (BBA)-General Subjects, 2017 - Elsevier
Cells are highly organized entities that rely on intricate addressing mechanisms to sort their
constituent molecules to precise subcellular locations. These processes are crucial for cells …
constituent molecules to precise subcellular locations. These processes are crucial for cells …
Roles of Puf proteins in mRNA degradation and translation
MA Miller, WM Olivas - Wiley Interdisciplinary Reviews: RNA, 2011 - Wiley Online Library
Puf proteins are regulators of diverse eukaryotic processes including stem cell maintenance,
organelle biogenesis, oogenesis, neuron function, and memory formation. At the molecular …
organelle biogenesis, oogenesis, neuron function, and memory formation. At the molecular …