Malignant pleural mesothelioma: history, controversy, and future of a man-made epidemic

OD Røe, GM Stella - Asbestos and Mesothelioma, 2017 - Springer
Asbestos (Greek, inextinguishable) is the term of a family of naturally occurring minerals that
have been used in small scale since ancient times. Industrialization demanded increased …

ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma

A Scherpereel, I Opitz, T Berghmans… - European respiratory …, 2020 - Eur Respiratory Soc
The European Respiratory Society (ERS)/European Society of Thoracic Surgeons
(ESTS)/European Association for Cardio-Thoracic Surgery (EACTS)/European Society for …

Frequency of germline mutations in cancer susceptibility genes in malignant mesothelioma

V Panou, M Gadiraju, A Wolin, CM Weipert… - Journal of Clinical …, 2018 - ascopubs.org
Purpose The aim of the current study was to determine the prevalence and clinical
predictors of germline cancer susceptibility mutations in patients with malignant …

[HTML][HTML] Genomics and epigenetics of malignant mesothelioma

AP Sage, VD Martinez, BC Minatel, ME Pewarchuk… - High-throughput, 2018 - mdpi.com
Malignant mesothelioma is an aggressive and lethal asbestos-related disease. Diagnosis of
malignant mesothelioma is particularly challenging and is further complicated by the lack of …

[HTML][HTML] Targeted next-generation sequencing of cancer genes in advanced stage malignant pleural mesothelioma: a retrospective study

ML Iacono, V Monica, L Righi, F Grosso… - Journal of thoracic …, 2015 - Elsevier
Introduction Malignant pleural mesothelioma (MPM) is a rare malignant disease, and the
understanding of molecular pathogenesis has lagged behind other malignancies. Methods …

Germline BAP1 mutational landscape of asbestos-exposed malignant mesothelioma patients with family history of cancer

JA Ohar, M Cheung, J Talarchek, SE Howard… - Cancer research, 2016 - AACR
Heritable mutations in the BAP1 tumor suppressor gene predispose individuals to
mesothelioma and other cancers. However, a large-scale assessment of germline BAP1 …

ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma

I Opitz, A Scherpereel, T Berghmans… - European journal of …, 2020 - academic.oup.com
Abstract The European Respiratory Society (ERS)/European Society of Thoracic Surgeons
(ESTS)/European Association for Cardio-Thoracic Surgery (EACTS)/European Society for …

[HTML][HTML] Germline mutations in DNA repair genes predispose asbestos-exposed patients to malignant pleural mesothelioma

M Betti, E Casalone, D Ferrante, A Aspesi, G Morleo… - Cancer letters, 2017 - Elsevier
Malignant pleural mesothelioma (MPM) is a rare, aggressive cancer caused by asbestos
exposure. An inherited predisposition has been suggested to explain multiple cases in the …

Sensitivity to asbestos is increased in patients with mesothelioma and pathogenic germline variants in BAP1 or other DNA repair genes

M Betti, A Aspesi, D Ferrante, M Sculco… - Genes …, 2018 - Wiley Online Library
Pathogenic germline variants in the BAP1 tumor suppressor gene can cause a cancer
syndrome called BAP1 tumor predisposition syndrome (BAP1‐TPDS), which is …

Inference on germline BAP1 mutations and asbestos exposure from the analysis of familial and sporadic mesothelioma in a high‐risk area

M Betti, E Casalone, D Ferrante… - Genes …, 2015 - Wiley Online Library
Inherited loss‐of‐function mutations in the BAP1 oncosuppressor gene are responsible for
an inherited syndrome with predisposition to malignant mesothelioma (MM), uveal and …