Depriving iron supply to the virus represents a promising adjuvant therapeutic against viral survival

W Liu, S Zhang, S Nekhai, S Liu - Current clinical microbiology reports, 2020 - Springer
Purpose of the review The ongoing outbreak of novel coronavirus pneumonia (COVID-19)
caused by the 2019 novel coronavirus (SARS-CoV-2) in China is lifting widespread …

The transferrin receptor: the cellular iron gate

E Gammella, P Buratti, G Cairo, S Recalcati - Metallomics, 2017 - academic.oup.com
Abstract The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-
dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis …

Feline panleukopenia: a re-emergent disease

VR Barrs - Veterinary Clinics: Small Animal Practice, 2019 - vetsmall.theclinics.com
Feline panleukopenia (FPL) is the clinical disease syndrome caused by infection with
Carnivore protoparvovirus 1. Both feline parvovirus (FPV; formerly FPL virus) and canine …

Human transferrin receptor can mediate SARS-CoV-2 infection

Z Liao, C Wang, X Tang, M Yang… - Proceedings of the …, 2024 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been
detected in almost all organs of coronavirus disease-19 patients, although some organs do …

Crossing the iron gate: why and how transferrin receptors mediate viral entry

M Wessling-Resnick - Annual review of nutrition, 2018 - annualreviews.org
Because both the host and pathogen require iron, the innate immune response carefully
orchestrates control over iron metabolism to limit its availability during times of infection …

Viral infection and iron metabolism

H Drakesmith, A Prentice - Nature Reviews Microbiology, 2008 - nature.com
Fundamental cellular operations, including DNA synthesis and the generation of ATP,
require iron. Viruses hijack cells in order to replicate, and efficient replication needs an iron …

A viral phospholipase A2 is required for parvovirus infectivity

Z Zádori, J Szelei, MC Lacoste, Y Li, S Gariépy… - Developmental cell, 2001 - cell.com
Sequence analysis revealed phospholipase A 2 (PLA 2) motifs in capsid proteins of
parvoviruses. Although PLA 2 activity is not known to exist in viruses, putative PLA 2 s from …

Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses

SR Radoshitzky, J Abraham, CF Spiropoulou, JH Kuhn… - Nature, 2007 - nature.com
At least five arenaviruses cause viral haemorrhagic fevers in humans. Lassa virus, an Old
World arenavirus, uses the cellular receptor α-dystroglycan to infect cells. Machupo …

Canine parvovirus: current perspective

S Nandi, M Kumar - Indian Journal of virology, 2010 - Springer
Abstract Canine parvovirus 2 (CPV-2) has been considered to be an important pathogen of
domestic and wild canids and has spread worldwide since its emergence in 1978. It has …

Identification of transferrin receptor 1 as a hepatitis C virus entry factor

DN Martin, SL Uprichard - Proceedings of the National …, 2013 - National Acad Sciences
Hepatitis C virus (HCV) is a liver tropic pathogen that affects∼ 170 million people worldwide
and causes liver pathologies including fibrosis, cirrhosis, steatosis, iron overload, and …