SARS‐CoV‐2 Omicron variant: Immune escape and vaccine development

D Ao, T Lan, X He, J Liu, L Chen, DT Baptista‐Hon… - MedComm, 2022 - Wiley Online Library
New genetic variants of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
constantly emerge through unmitigated spread of the virus in the ongoing Coronavirus …

Sensitivity to vaccines, therapeutic antibodies, and viral entry inhibitors and advances to counter the SARS-CoV-2 Omicron variant

H Zhou, M Møhlenberg, JC Thakor… - Clinical microbiology …, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps evolving and
mutating into newer variants over time, which gain higher transmissibility, disease severity …

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

RR Goel, MM Painter, KA Lundgreen, SA Apostolidis… - Cell, 2022 - cell.com
We examined antibody and memory B cell responses longitudinally for∼ 9–10 months after
primary 2-dose SARS-CoV-2 mRNA vaccination and 3 months after a 3rd dose. Antibody …

SARS-CoV-2 Omicron BA. 1 and BA. 2 are attenuated in rhesus macaques as compared to Delta

N van Doremalen, M Singh, TA Saturday, CK Yinda… - Science …, 2022 - science.org
Since the emergence of SARS-CoV-2, five different variants of concern (VOCs) have been
identified: Alpha, Beta, Gamma, Delta, and Omicron. Because of confounding factors in the …

Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2

Z Fang, L Peng, R Filler, K Suzuki, A McNamara… - Nature …, 2022 - nature.com
The Omicron variant of SARS-CoV-2 recently swept the globe and showed high level of
immune evasion. Here, we generate an Omicron-specific lipid nanoparticle (LNP) mRNA …

[HTML][HTML] Breakthrough infections after COVID-19 vaccination: Insights, perspectives and challenges

E Amanatidou, A Gkiouliava, E Pella, M Serafidi… - Metabolism open, 2022 - Elsevier
Vaccination programs against SARS-CoV-2 constitute the mainstay of public health
interventions against the global COVID-19 pandemic. Currently available vaccines have …

ChAdOx1 nCoV-19 (AZD1222) or nCoV-19-Beta (AZD2816) protect Syrian hamsters against Beta Delta and Omicron variants

N van Doremalen, JE Schulz, DR Adney… - Nature …, 2022 - nature.com
Abstract ChAdOx1 nCoV-19 (AZD1222) is a replication-deficient simian adenovirus–
vectored vaccine encoding the spike (S) protein of SARS-CoV-2, based on the first …

Omicron BA. 1-containing mRNA-1273 boosters compared with the original COVID-19 vaccine in the UK: a randomised, observer-blind, active-controlled trial

IT Lee, CA Cosgrove, P Moore, C Bethune… - The Lancet Infectious …, 2023 - thelancet.com
Background The omicron BA. 1 bivalent booster is used globally. Previous open-label
studies of the omicron BA. 1 (Moderna mRNA-1273.214) booster showed superior …

SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals

SI Richardson, VS Madzorera, H Spencer… - Cell Host & Microbe, 2022 - cell.com
Summary The SARS-CoV-2 Omicron variant escapes neutralizing antibodies elicited by
vaccines or infection. However, whether Omicron triggers cross-reactive humoral responses …

A booster dose of Delta× Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants

IJ Lee, CP Sun, PY Wu, YH Lan, IH Wang… - Journal of biomedical …, 2022 - Springer
Background With the continuous emergence of new SARS-CoV-2 variants that feature
increased transmission and immune escape, there is an urgent demand for a better vaccine …