Importance Acute appendicitis is the most common abdominal surgical emergency in the
world, with an annual incidence of 96.5 to 100 cases per 100 000 adults. Observations The …

Background: Diagnostic work-up of acute appendicitis remains challenging. While some
guidelines advise to use a risk stratification based on clinical parameters, others use …

Neutralization of the SARS-CoV-2 Mu Variant The mu variant of SARS-CoV-2 was 10.6
times as resistant to neutralization by serum samples obtained from persons who had …

Importance Appendectomy remains the standard of care for uncomplicated acute
appendicitis despite several randomized clinical trials pointing to the safety and efficacy of …

Key Clinical Points Treatment of Acute Uncomplicated Appendicitis Patients with acute,
localized, uncomplicated appendicitis (approximately 80% of all appendicitis cases) are …

There is a clear need for simple resources to improve the quality of antibiotic prescribing
globally. The AWaRe book was designed as a tool to make the antibiotics section of the …

Antibiotics vs. Appendectomy for Appendicitis In this randomized trial comparing antibiotic
treatment with appendectomy in patients with appendicitis, the percentage of patients in the …

Importance Antibiotics are an effective and safe alternative to appendectomy for managing
uncomplicated acute appendicitis, but the optimal antibiotic regimen is not known. Objective …

Background This aim of this study was to provide an updated meta-analysis comparing
antibiotic therapy with appendicectomy in adults (16 years or older) with uncomplicated …

Background Appendicectomy remains the standard treatment for appendicitis. No
international consensus exists on the surgical urgency for acute uncomplicated appendicitis …