The modern antiretroviral treatment of human immunodeficiency virus (HIV-1) infection has
considerably lowered the incidence of opportunistic infections. With the exception of the …

One of the main challenges in the fight against HIV infection is to develop strategies that are
able to eliminate the persistent viral reservoir that harbours integrated, replication-competent …

Objective To test the hypothesis that coronavirus disease 2019 (COVID-19) has an impact
on the CNS by measuring plasma biomarkers of CNS injury. Methods We recruited 47 …

Background Cerebrospinal fluid (CSF) neurofilament light chain protein (NFL) is a sensitive
marker of neuronal injury in a variety of neurodegenerative conditions, including the CNS …

The retention of infected cells in a wide variety of tissues, often with distinct viral and cellular
characteristics, underscores the importance of studying tissue reservoirs in the development …

Neurological involvement in HIV is often associated with cognitive impairment. Although
severe and progressive neurocognitive impairment has become rare in HIV clinics in the era …

HIV invades the brain during acute infection. Yet, it is unknown whether long-lived infected
brain cells release productive virus that can egress from the brain to re-seed peripheral …

Cross-sectional studies show that around half of individuals infected with HIV-1 have some
degree of cognitive impairment despite the use of antiretroviral drugs. However, prevalence …

Early in the HIV epidemic, the central nervous system (CNS) was recognized as a target of
infection and injury in the advanced stages of disease. Though the most severe forms of HIV …

BACKGROUND Persistence of HIV in sanctuary sites despite antiretroviral therapy (ART)
presents a barrier to HIV remission and may affect neurocognitive function. We assessed …