[HTML][HTML] High-content CRISPR screening
CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …
interrogation of gene function in a wide range of applications and species. In pooled …
Current applications and future perspective of CRISPR/Cas9 gene editing in cancer
SW Wang, C Gao, YM Zheng, L Yi, JC Lu, XY Huang… - Molecular cancer, 2022 - Springer
Clustered regularly interspaced short palindromic repeats (CRISPR) system provides
adaptive immunity against plasmids and phages in prokaryotes. This system inspires the …
adaptive immunity against plasmids and phages in prokaryotes. This system inspires the …
[HTML][HTML] Multimodal analysis of composition and spatial architecture in human squamous cell carcinoma
To define the cellular composition and architecture of cutaneous squamous cell carcinoma
(cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and …
(cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and …
Active eosinophils regulate host defence and immune responses in colitis
In the past decade, single-cell transcriptomics has helped to uncover new cell types and
states and led to the construction of a cellular compendium of health and disease. Despite …
states and led to the construction of a cellular compendium of health and disease. Despite …
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing
AP Deshmukh, SV Vasaikar… - Proceedings of the …, 2021 - National Acad Sciences
The epithelial-to-mesenchymal transition (EMT) plays a critical role during normal
development and in cancer progression. EMT is induced by various signaling pathways …
development and in cancer progression. EMT is induced by various signaling pathways …
[HTML][HTML] Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states
The underpinnings of cancer metastasis remain poorly understood, in part due to a lack of
tools for probing their emergence at high resolution. Here we present macsGESTALT, an …
tools for probing their emergence at high resolution. Here we present macsGESTALT, an …
EMT factors and metabolic pathways in cancer
I Georgakopoulos-Soares, DV Chartoumpekis… - Frontiers in …, 2020 - frontiersin.org
The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …
Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer
Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with
certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However …
certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However …
In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition
The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each
comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which …
comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which …