Natural killer cell specificity for viral infections

Q Hammer, T Rückert, C Romagnani - Nature immunology, 2018 - nature.com
Natural killer (NK) cells are lymphocytes that contribute to the early immune responses to
viruses. NK cells are innate immune cells that do not express rearranged antigen receptors …

Natural killer cells in HIV-1 infection and therapy

J Mikulak, F Oriolo, E Zaghi, C Di Vito, D Mavilio - Aids, 2017 - journals.lww.com
Natural killer (NK) cells are important effectors of innate immunity playing a key role in the
eradication and clearance of viral infections. Over the recent years, several studies have …

Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1

WF Garcia-Beltran, A Hölzemer, G Martrus… - Nature …, 2016 - nature.com
The activating natural killer (NK)-cell receptor KIR3DS1 has been linked to the outcome of
various human diseases, including delayed progression of disease caused by human …

[HTML][HTML] Human leukocyte antigen F presents peptides and regulates immunity through interactions with NK cell receptors

CL Dulberger, CP McMurtrey, A Hölzemer, KE Neu… - Immunity, 2017 - cell.com
Evidence is mounting that the major histocompatibility complex (MHC) molecule HLA-F
(human leukocyte antigen F) regulates the immune system in pregnancy, infection, and …

KIR3DL1 and HLA-B density and binding calibrate NK education and response to HIV

JE Boudreau, TJ Mulrooney, JB Le Luduec… - The Journal of …, 2016 - journals.aai.org
NK cells recognize self-HLA via killer Ig-like receptors (KIR). Homeostatic HLA expression
signals for inhibition via KIR, and downregulation of HLA, a common consequence of viral …

A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44

A Niehrs, WF Garcia-Beltran, PJ Norman… - Nature …, 2019 - nature.com
Natural killer (NK) cells can recognize virus-infected and stressed cells using activating and
inhibitory receptors, many of which interact with HLA class I. Although early studies also …

The evolution of natural killer cell receptors

P Carrillo-Bustamante, C Keşmir, RJ de Boer - Immunogenetics, 2016 - Springer
Natural killer (NK) cells are immune cells that play a crucial role against viral infections and
tumors. To be tolerant against healthy tissue and simultaneously attack infected cells, the …

Human KIR repertoires: shaped by genetic diversity and evolution

AR Manser, S Weinhold, M Uhrberg - Immunological reviews, 2015 - Wiley Online Library
Killer cell immunoglobulin‐like receptors (KIR s) on natural killer (NK) cells are crucially
involved in the control of cancer development and virus infection by probing cells for proper …

[HTML][HTML] Activating KIR2DS4 is expressed by uterine NK cells and contributes to successful pregnancy

PR Kennedy, O Chazara, L Gardner… - The Journal of …, 2016 - journals.aai.org
Tissue-specific NK cells are abundant in the pregnant uterus and interact with invading
placental trophoblast cells that transform the maternal arteries to increase the fetoplacental …

A bird's eye view of NK cell receptor interactions with their MHC class I ligands

PM Saunders, JP Vivian, GM O'Connor… - Immunological …, 2015 - Wiley Online Library
The surveillance of target cells by natural killer (NK) cells utilizes an ensemble of inhibitory
and activating receptors, many of which interact with major histocompatibility complex …