Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in
mammals. Among them are the hydrophilic cardenolide ouabain and the more hydrophobic …

The sodium pump, Na+/K+-ATPase, could be an important target for the development of anti-
cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion …

The Na+, K+-ATPase is a ubiquitous membrane transport protein in mammalian cells,
responsible for establishing and maintaining high K+ and low Na+ in the cytoplasm required …

Digitalis-like compounds (DLC) are a family of steroid hormones synthesized in and
released from the adrenal gland. DLC, the structure of which resembles that of plant cardiac …

The signaling function of the Na/K-ATPase has been established for 20 years and is widely
accepted in the field, with many excellent reports and reviews not cited here. Even though …

High salt consumption contributes to the development of hypertension and is considered an
independent risk factor for vascular remodeling, cardiac hypertrophy, and stroke incidence …

Astrocytes are the main cell type responsible for the regulation of brain homeostasis,
including the maintenance of ion gradients and neurotransmitter clearance. These …

Stimulus-dependent elevation of intracellular Ca2+ ([Ca2+] i) affects the expression of
numerous genes–a phenomenon known as excitation-transcription coupling. Recently, we …

Background—We studied the growth-promoting effects of 2 sodium pump–selective
cardiotonic steroids, ouabain and marinobufagenin, on cultured cells from vascular smooth …

It is generally accepted that electrochemical gradients of monovalent ions across the plasma
membrane, created by the coupled function of pumps, carriers and channels, are involved in …