Y Octavia, CG Tocchetti, KL Gabrielson… - Journal of molecular and …, 2012 - Elsevier
The utility of anthracycline antineoplastic agents in the clinic is compromised by the risk of cardiotoxicity. It has been calculated that approximately 10% of patients treated with …
The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1 and-2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas …
Hypertension (HTN) is one of the most prevalent diseases worldwide and is among the most important risk factors for cardiovascular and cerebrovascular complications. It is currently …
The onset of cardiomyopathy is a common feature in sepsis, with relevant effects on its pathophysiology and clinical care. Septic cardiomyopathy is characterized by reduced left …
MW Merx, C Weber - Circulation, 2007 - Am Heart Assoc
Sepsis is generally viewed as a disease aggravated by an inappropriate immune response encountered in the afflicted individual. As an important organ system frequently …
F Böhm, J Pernow - Cardiovascular research, 2007 - academic.oup.com
Abstract Endothelin (ET)-1 is a potent vasoconstrictor peptide originally isolated from endothelial cells. Its production is stimulated in a variety of different cell types under the …
Adrenergic receptors (AR) are G-protein-coupled receptors (GPCRs) that have a crucial role in cardiac physiology in health and disease. Alpha1-ARs signal through G α q, and signaling …
M Iglarz, C Binkert, K Morrison, W Fischli… - … of Pharmacology and …, 2008 - ASPET
Macitentan, also called Actelion-1 or ACT-064992 [N-[5-(4-bromophenyl)-6-(2-(5- bromopyrimidin-2-yloxy) ethoxy)-pyrimidin-4-yl]-N′-propylaminosulfonamide], is a new …
RM Witteles, MB Fowler - Journal of the American College of Cardiology, 2008 - jacc.org
Increasing evidence points to insulin resistance as a primary etiologic factor in the development of nonischemic heart failure (HF). The myocardium normally responds to injury …