Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

The ongoing worldwide increase in life expectancy portends a rising prevalence of age-
related cardiovascular (CV) diseases in the coming decades that demands a deeper …

Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-
associated decline in organ functions in mammals; however, the specific cell types and gene …

The primary goal of vaccination is the prevention of pathogen-specific infection. The indirect
consequences may include maintenance of homeostasis through prevention of infection …

Traditionally, genetics and lifestyle are considered as main determinants of aging-
associated pathological conditions. Accumulating evidence, however, suggests that risk of …

The aging process is driven by multiple mechanisms that lead to changes in energy
production, oxidative stress, homeostatic dysregulation and eventually to loss of functionality …

COVID-19 pandemic caused by the Severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has inflicted a global health challenge. Although the overwhelming …

Immunopsychiatric field has rapidly accumulated evidence demonstrating the involvement of
both innate and adaptive immune components in psychotic disorders such as …

Aging is characterized by progressive loss of organ and tissue function, and the immune
system is no exception to that inevitable principle. Of all the age-related changes in the …