Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts

AC McKee, TD Stein, BR Huber, JF Crary… - Acta …, 2023 - Springer
Over the last 17 years, there has been a remarkable increase in scientific research
concerning chronic traumatic encephalopathy (CTE). Since the publication of NINDS–NIBIB …

Applying the Bradford Hill criteria for causation to repetitive head impacts and chronic traumatic encephalopathy

CJ Nowinski, SC Bureau, ME Buckland… - Frontiers in …, 2022 - frontiersin.org
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with a
history of repetitive head impacts (RHI). CTE was described in boxers as early as the 1920s …

Tau-targeting therapies for Alzheimer disease: current status and future directions

EE Congdon, C Ji, AM Tetlow, Y Jiang… - Nature Reviews …, 2023 - nature.com
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …

SARS‐CoV‐2 targets neurons of 3D human brain organoids

A Ramani, L Müller, PN Ostermann, E Gabriel… - The EMBO …, 2020 - embopress.org
COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency.
COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports …

Tau-targeting therapies for Alzheimer disease

EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

[HTML][HTML] Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

K Koikawa, S Kibe, F Suizu, N Sekino, N Kim, TD Manz… - Cell, 2021 - cell.com
Pancreatic ductal adenocarcinoma (PDAC) is characterized by notorious resistance to
current therapies attributed to inherent tumor heterogeneity and highly desmoplastic and …

Tau and neuroinflammation in Alzheimer's disease: Interplay mechanisms and clinical translation

Y Chen, Y Yu - Journal of neuroinflammation, 2023 - Springer
Alzheimer's Disease (AD) contributes to most cases of dementia. Its prominent
neuropathological features are the extracellular neuritic plaques and intercellular …

Neuroimmunology of traumatic brain injury: time for a paradigm shift

YN Jassam, S Izzy, M Whalen, DB McGavern… - Neuron, 2017 - cell.com
Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …

Tau in physiology and pathology

Y Wang, E Mandelkow - Nature reviews neuroscience, 2016 - nature.com
Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …

Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia

NSN Graham, DJ Sharp - Journal of Neurology, Neurosurgery & …, 2019 - jnnp.bmj.com
Traumatic brain injury (TBI) leads to increased rates of dementia, including Alzheimer's
disease. The mechanisms by which trauma can trigger neurodegeneration are increasingly …