Recent advances in machine learning-based models for prediction of antiviral peptides

F Ali, H Kumar, W Alghamdi, FA Kateb… - Archives of Computational …, 2023 - Springer
Viruses have killed and infected millions of people across the world. It causes several
chronic diseases like COVID-19, HIV, and hepatitis. To cope with such diseases and virus …

Deepstacked-AVPs: predicting antiviral peptides using tri-segment evolutionary profile and word embedding based multi-perspective features with deep stacking …

S Akbar, A Raza, Q Zou - BMC bioinformatics, 2024 - Springer
Background Viral infections have been the main health issue in the last decade. Antiviral
peptides (AVPs) are a subclass of antimicrobial peptides (AMPs) with substantial potential to …

Prediction of amyloid proteins using embedded evolutionary & ensemble feature selection based descriptors with eXtreme gradient boosting model

S Akbar, H Ali, A Ahmad, MR Sarker, A Saeed… - IEEE …, 2023 - ieeexplore.ieee.org
Amyloid proteins (AMYs) are usually an aggregate of insoluble fibrous that have major
pathogenic effects on various tissues. However, its abnormal deposition may lead to several …

A bi-layer model for identification of piwiRNA using deep neural learning

A Adnan, W Hongya, F Ali, M Khalid… - Journal of …, 2023 - Taylor & Francis
Abstract piwiRNA is a kind of non-coding RNA (ncRNA) that cannot be translated into
proteins. It helps in understanding the study of gametes generation and regulation of gene …

Machine learning-based model for accurate identification of druggable proteins using light extreme gradient boosting

O Alghushairy, F Ali, W Alghamdi, M Khalid… - Journal of …, 2023 - Taylor & Francis
The identification of druggable proteins (DPs) is significant for the development of new
drugs, personalized medicine, understanding of disease mechanisms, drug repurposing …

Leveraging a meta-learning approach to advance the accuracy of Nav blocking peptides prediction

W Shoombuatong, N Homdee, N Schaduangrat… - Scientific Reports, 2024 - nature.com
The voltage-gated sodium (Nav) channel is a crucial molecular component responsible for
initiating and propagating action potentials. While the α subunit, forming the channel pore …

Accurate Prediction of Antifreeze Protein from Sequences through Natural Language Text Processing and Interpretable Machine Learning Approaches

S Dhibar, B Jana - The Journal of Physical Chemistry Letters, 2023 - ACS Publications
Antifreeze proteins (AFPs) bind to growing iceplanes owing to their structural
complementarity nature, thereby inhibiting the ice-crystal growth by thermal hysteresis …

FRP-XGBoost: Identification of ferroptosis-related proteins based on multi-view features

L Lin, Y Long, J Liu, D Deng, Y Yuan, L Liu… - International Journal of …, 2024 - Elsevier
Ferroptosis represents a novel form of programmed cell death. Pan-cancer bioinformatics
analysis indicates that identifying and modulating ferroptosis offer innovative approaches for …

DPI_CDF: druggable protein identifier using cascade deep forest

M Arif, G Fang, A Ghulam, S Musleh, T Alam - BMC bioinformatics, 2024 - Springer
Background Drug targets in living beings perform pivotal roles in the discovery of potential
drugs. Conventional wet-lab characterization of drug targets is although accurate but …

An ensemble computational model for prediction of clathrin protein by coupling machine learning with discrete cosine transform

M Khalid, F Ali, W Alghamdi, A Alzahrani… - Journal of …, 2024 - Taylor & Francis
Clathrin protein (CP) plays a pivotal role in numerous cellular processes, including
endocytosis, signal transduction, and neuronal function. Dysregulation of CP has been …